Translational Psychiatry

TABLE 1

FROM:

The role of 5-HT1A receptors in mediating acute negative effects of antidepressants: implications in pediatric depression

K A Rahn, Y-J Cao, C W Hendrix and A I Kaplin

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Table 1. Dosing recommendations for paroxetine, citalopram, sertraline, venlafaxine and fluvoxamine

Dosing dayFluoxetine
Cave
ParoxetineCitalopramSertralineVenlafaxineFluvoxamine
  Dose every 24hCaveDose every 24hCaveDose every 24hCaveDose every 24hCaveDose every 12hCave
130.819.28.711.510.423.711.682.8102.420.515.1
255.824.615.713.418.828.920.9111.2185.421.027.3
374.828.821.014.725.133.128.0134.1248.425.036.5
489.531.825.215.730.136.433.5152.6297.229.043.7
5101.033.628.416.634.039.437.9166.5335.531.049.3
6110.135.431.017.437.141.341.3178.2365.933.053.8
7117.536.033.017.939.543.144.0187.7390.334.057.4
8123.437.834.718.541.544.646.2195.3409.836.060.3
9128.137.836.018.843.145.848.0201.6425.737.062.6
10132.039.037.119.244.446.949.5206.1438.537.064.5
11135.139.038.019.545.547.550.6210.6448.938.066.0
12137.739.638.719.646.348.351.6213.8457.439.067.2
13139.839.639.319.847.048.852.4216.5464.339.068.3
14141.540.239.820.047.649.153.0218.7470.040.069.1
15142.940.240.220.248.149.753.6220.5474.740.069.8
16144.040.240.520.348.449.854.0222.3478.540.070.3
17145.040.840.820.348.850.054.3223.2481.641.070.8
18145.740.841.020.449.050.354.6224.1484.240.071.2
19146.440.841.220.549.250.654.9225.0486.341.071.5
20146.940.841.320.449.450.655.1225.9488.041.071.7
21147.340.841.420.649.650.655.2226.4489.441.071.9
22147.740.841.520.649.750.755.3226.8490.641.072.1
23148.041.441.620.649.851.055.5227.3491.541.072.3
24148.240.841.720.749.850.855.5227.3492.341.072.4
25148.440.841.720.649.951.055.6227.7493.041.072.5
26148.541.441.820.750.051.155.7228.2493.541.072.6
27148.740.841.820.650.050.955.7228.2494.041.072.6
28148.841.441.920.850.051.255.8228.2494.341.072.7
29148.940.841.920.650.151.155.8228.6494.641.072.7
30149.041.441.920.750.151.055.8228.6494.941.072.8

 If paroxetine, citalopram, sertraline, venlafaxine and fluvoxamine are given based on the following table, their daily mean blood concentrations (Cave) will be matched to that of fluoxetine at 40mg every 24h. Dose is in mg. Cave is in ngml−1. Patient's weight is assumed to be 70kg. Cave for venlafaxine is the combination of venlafaxine and its active metabolite, O-desmethylvenlafaxine.

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