White matter disease

Definition

White matter disease refers to a group of heterogeneous disorders that involve degeneration of the white matter of the brain.

Featured

Latest Research and Reviews

  • Reviews |

    Inadequate remyelination is central to degeneration and disability in patients with multiple sclerosis (MS); however, all currently approved therapies for MS are primarily immunomodulatory. Here, Martin Stangel and colleagues review our current knowledge of remyelination in MS, discuss results from clinical trials of remyelination-enhancing therapies, and evaluate the opportunities for future regenerative treatments.

    • Martin Stangel
    • , Tanja Kuhlmann
    • , Paul M. Matthews
    •  & Trevor J. Kilpatrick
  • Reviews |

    Promoting remyelination may be an effective therapeutic strategy for various disorders that are characterized by a loss of myelin, including multiple sclerosis. In this Review, Franklin and ffrench-Constant discuss recent developments in our understanding of remyelination and the efforts that are underway to enhance this process.

    • Robin J. M. Franklin
    •  & Charles ffrench-Constant
  • Research |

    High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.

    • Nicola Wilck
    • , Mariana G. Matus
    • , Sean M. Kearney
    • , Scott W. Olesen
    • , Kristoffer Forslund
    • , Hendrik Bartolomaeus
    • , Stefanie Haase
    • , Anja Mähler
    • , András Balogh
    • , Lajos Markó
    • , Olga Vvedenskaya
    • , Friedrich H. Kleiner
    • , Dmitry Tsvetkov
    • , Lars Klug
    • , Paul I. Costea
    • , Shinichi Sunagawa
    • , Lisa Maier
    • , Natalia Rakova
    • , Valentin Schatz
    • , Patrick Neubert
    • , Christian Frätzer
    • , Alexander Krannich
    • , Maik Gollasch
    • , Diana A. Grohme
    • , Beatriz F. Côrte-Real
    • , Roman G. Gerlach
    • , Marijana Basic
    • , Athanasios Typas
    • , Chuan Wu
    • , Jens M. Titze
    • , Jonathan Jantsch
    • , Michael Boschmann
    • , Ralf Dechend
    • , Markus Kleinewietfeld
    • , Stefan Kempa
    • , Peer Bork
    • , Ralf A. Linker
    • , Eric J. Alm
    •  & Dominik N. Müller
  • Research | | open

    CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “pathogenic” mouse TH 17 but distinct from “non-pathogenic” mouse TH 17.

    • Dan Hu
    • , Samuele Notarbartolo
    • , Tom Croonenborghs
    • , Bonny Patel
    • , Ron Cialic
    • , Tun-Hsiang Yang
    • , Dominik Aschenbrenner
    • , Karin M. Andersson
    • , Marco Gattorno
    • , Minh Pham
    • , Pia Kivisakk
    • , Isabelle V. Pierre
    • , Youjin Lee
    • , Karun Kiani
    • , Maria Bokarewa
    • , Emily Tjon
    • , Nathalie Pochet
    • , Federica Sallusto
    • , Vijay K. Kuchroo
    •  & Howard L. Weiner

News and Comment