Virus structures

Definition

Virus structures are the physical components of a virus particle, including its genome and structural proteins.

Latest Research and Reviews

  • Research | | open

    Coronaviruses have a relatively high mutation rate, potentially allowing fast adaptation to changing pressures. Here, Wong et al. provide the structure of the receptor-binding domain (RBD) of the human coronavirus HCoV-229E and its receptor and analyze the evolution of the RBD over the past 50 years.

    • Alan H. M. Wong
    • , Aidan C. A. Tomlinson
    • , Dongxia Zhou
    • , Malathy Satkunarajah
    • , Kevin Chen
    • , Chetna Sharon
    • , Marc Desforges
    • , Pierre J. Talbot
    •  & James M. Rini
  • Research | | open

    An efficient vaccine for human metapneumovirus (hMPV) will likely rely on neutralizing antibodies against the fusion protein (F). Here, the authors determine the crystal structure of pre-fusion-stabilized hMPV F and identify a dense glycan shield that affects generation of neutralizing antibodies.

    • Michael B. Battles
    • , Vicente Más
    • , Eduardo Olmedillas
    • , Olga Cano
    • , Mónica Vázquez
    • , Laura Rodríguez
    • , José A. Melero
    •  & Jason S. McLellan
  • Reviews |

    One of the most prominent features of archaea is the extraordinary diversity of their viruses. In this Review, Prangishvili et al. summarize their morphological diversity, the molecular biology of their life cycles and virus–host interactions, and discuss their evolution and their role in the global virosphere.

    • David Prangishvili
    • , Dennis H. Bamford
    • , Patrick Forterre
    • , Jaime Iranzo
    • , Eugene V. Koonin
    •  & Mart Krupovic
  • Research |

    Application of cryo-electron tomography and subtomogram averaging to determine the structure of the Ebola virus nucleocapsid within intact viruses and recombinant nucleocapsid-like assemblies.

    • William Wan
    • , Larissa Kolesnikova
    • , Mairi Clarke
    • , Alexander Koehler
    • , Takeshi Noda
    • , Stephan Becker
    •  & John A. G. Briggs
    Nature 551, 394–397
  • Research | | open

    The rod-shaped virus APBV1 is among the most thermostable viruses known. Here, Ptchelkine et al. determine its structure at near-atomic resolution, show that the DNA is packed as left-handed superhelix and identify extended hydrophobic interfaces that likely contribute to the extreme thermostability of the capsid.

    • Denis Ptchelkine
    • , Ashley Gillum
    • , Tomohiro Mochizuki
    • , Soizick Lucas-Staat
    • , Ying Liu
    • , Mart Krupovic
    • , Simon E. V. Phillips
    • , David Prangishvili
    •  & Juha T. Huiskonen

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