Virus structures

Virus structures are the physical components of a virus particle, including its genome and structural proteins.

Latest Research and Reviews

  • Research | | open

    Here, the authors present the cryo-EM structure of the archaeal virus SH1 at 3.8 Å resolution and show how the major capsid proteins assemble into hetero-hexamers, providing insights into the assembly process of this and related PRD1-adeno lineage viruses.

    • Luigi De Colibus
    • , Elina Roine
    • , Thomas S. Walter
    • , Serban L. Ilca
    • , Xiangxi Wang
    • , Nan Wang
    • , Alan M. Roseman
    • , Dennis Bamford
    • , Juha T. Huiskonen
    •  & David I. Stuart
  • Research | | open

    Here, the authors present the cryo-EM structures of two archaeal, halophilic, internal membrane-containing icosahedral viruses at 3.7 and 3.8 Å resolution, providing insights into the assembly process of these and related PRD1-adeno lineage viruses.

    • Isaac Santos-Pérez
    • , Diego Charro
    • , David Gil-Carton
    • , Mikel Azkargorta
    • , Felix Elortza
    • , Dennis H. Bamford
    • , Hanna M. Oksanen
    •  & Nicola G. A. Abrescia
  • Research | | open

    Genome release of enteroviruses relies on exposure to acidic pH, but the mechanism of uncoating remains unclear. Here, Buchta et al. show that echovirus 18 loses one to three adjacent capsid-protein pentamers, resulting in an opening of more than 120 Å for genome release.

    • David Buchta
    • , Tibor Füzik
    • , Dominik Hrebík
    • , Yevgen Levdansky
    • , Lukáš Sukeník
    • , Liya Mukhamedova
    • , Jana Moravcová
    • , Robert Vácha
    •  & Pavel Plevka
  • Research | | open

    Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a mouse model.

    • Jan Hellert
    • , Andrea Aebischer
    • , Kerstin Wernike
    • , Ahmed Haouz
    • , Emiliana Brocchi
    • , Sven Reiche
    • , Pablo Guardado-Calvo
    • , Martin Beer
    •  & Félix A. Rey
  • Research | | open

    Nai-Chi Chen et al. solved the structures of two shrimp nodaviruses, focusing on the major domains to improve understanding of capsid organization. By combining cryo-EM and x-ray crystallography, the authors were able to observe the structures at a high resolution.

    • Nai-Chi Chen
    • , Masato Yoshimura
    • , Naoyuki Miyazaki
    • , Hong-Hsiang Guan
    • , Phimonphan Chuankhayan
    • , Chien-Chih Lin
    • , Shao-Kang Chen
    • , Pei-Ju Lin
    • , Yen-Chieh Huang
    • , Kenji Iwasaki
    • , Atsushi Nakagawa
    • , Sunney I. Chan
    •  & Chun-Jung Chen
  • Research | | open

    Here, the authors present the structure of the HIV envelope (Env) protein from a transmitted founder virus and show that, while the overall structure of the Env trimer is similar to other closed trimers, the fusion peptide is buried in the hydrophobic core of the trimer, which is similar to open state trimers.

    • Neeti Ananthaswamy
    • , Qianglin Fang
    • , Wadad AlSalmi
    • , Swati Jain
    • , Zhenguo Chen
    • , Thomas Klose
    • , Yingyuan Sun
    • , Yue Liu
    • , Marthandan Mahalingam
    • , Subhash Chand
    • , Sodsai Tovanabutra
    • , Merlin L. Robb
    • , Michael G. Rossmann
    •  & Venigalla B. Rao

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