Viral reservoirs

Viral reservoirs are an anatomical site in which viruses accumulate and persist.

Latest Research and Reviews

  • Research |

    An assay to measure the latent HIV-1 reservoir that separately quantifies intact and defective proviruses will facilitate evaluation of HIV-1 cure strategies by measuring the provirues that pose a barrier to cure.

    • Katherine M. Bruner
    • , Zheng Wang
    • , Francesco R. Simonetti
    • , Alexandra M. Bender
    • , Kyungyoon J. Kwon
    • , Srona Sengupta
    • , Emily J. Fray
    • , Subul A. Beg
    • , Annukka A. R. Antar
    • , Katharine M. Jenike
    • , Lynn N. Bertagnolli
    • , Adam A. Capoferri
    • , Joshua T. Kufera
    • , Andrew Timmons
    • , Christopher Nobles
    • , John Gregg
    • , Nikolas Wada
    • , Ya-Chi Ho
    • , Hao Zhang
    • , Joseph B. Margolick
    • , Joel N. Blankson
    • , Steven G. Deeks
    • , Frederic D. Bushman
    • , Janet D. Siliciano
    • , Gregory M. Laird
    •  & Robert F. Siliciano
    Nature 566, 120-125
  • Research |

    Měnglà virus (MLAV) is a phylogenetically distinct bat filovirus, whose genome shares 32–54% nucleotide sequence identity with known filoviruses. MLAV glycoprotein-typed pseudo-types can transduce cell lines derived from humans, monkeys, dogs, hamsters and bats.

    • Xing-Lou Yang
    • , Chee Wah Tan
    • , Danielle E. Anderson
    • , Ren-Di Jiang
    • , Bei Li
    • , Wei Zhang
    • , Yan Zhu
    • , Xiao Fang Lim
    • , Peng Zhou
    • , Xiang-Ling Liu
    • , Wuxiang Guan
    • , Libiao Zhang
    • , Shi-Yue Li
    • , Yun-Zhi Zhang
    • , Lin-Fa Wang
    •  & Zheng-Li Shi
    Nature Microbiology 4, 390-395
  • Reviews |

    Coronaviruses have a broad host range and distribution, and some highly pathogenic lineages have spilled over to humans and animals. Here, Cui, Li and Shi explore the viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome.

    • Jie Cui
    • , Fang Li
    •  & Zheng-Li Shi
  • Reviews |

    Influenza A viruses cause pandemics when they cross between species. In this Review, Barclay and colleagues examine the host barriers that influenza A viruses must overcome to initiate a pandemic in humans and describe how, on crossing the species barrier, the virus mutates to establish new interactions with the human host.

    • Jason S. Long
    • , Bhakti Mistry
    • , Stuart M. Haslam
    •  & Wendy S. Barclay
  • Research | | open

    HIV infected cells persist for decades in patients under ART, but the mechanisms responsible remain unclear. Here, Reeves et al. use modeling approaches adapted from ecology to show that cellular proliferation, rather than viral replication, generates a majority of infected cells during ART.

    • Daniel B. Reeves
    • , Elizabeth R. Duke
    • , Thor A. Wagner
    • , Sarah E. Palmer
    • , Adam M. Spivak
    •  & Joshua T. Schiffer
  • Research |

    In monkeys infected with an AIDS-like virus, a combination of a broadly neutralizing antibody and an immune stimulator during antiretroviral therapy suppressed viral rebound after antiretroviral drug discontinuation.

    • Erica N. Borducchi
    • , Jinyan Liu
    • , Joseph P. Nkolola
    • , Anthony M. Cadena
    • , Wen-Han Yu
    • , Stephanie Fischinger
    • , Thomas Broge
    • , Peter Abbink
    • , Noe B. Mercado
    • , Abishek Chandrashekar
    • , David Jetton
    • , Lauren Peter
    • , Katherine McMahan
    • , Edward T. Moseley
    • , Elena Bekerman
    • , Joseph Hesselgesser
    • , Wenjun Li
    • , Mark G. Lewis
    • , Galit Alter
    • , Romas Geleziunas
    •  & Dan H. Barouch
    Nature 563, 360-364

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