Viral host response

The viral host response is the process by which a host interacts with and responds to viruses that it encounters. It includes various mechanisms, such as immune mechanisms that are elicited in an attempt to eliminate the virus or halt its growth.

Latest Research and Reviews

  • Research | | open

    SIRPa is most commonly known as a phagocytosis inhibitory receptor expressed by myeloid cells. Here the authors show SIRPa is expressed on a subset of CD8+ T cells with higher proliferative and effector activity during the chronic phase of the immune response to viral infection.

    • Lara M. Myers
    • , Michal Caspi Tal
    • , Laughing Bear Torrez Dulgeroff
    • , Aaron B. Carmody
    • , Ronald J. Messer
    • , Gunsagar Gulati
    • , Ying Ying Yiu
    • , Matthew M. Staron
    • , Cesar Lopez Angel
    • , Rahul Sinha
    • , Maxim Markovic
    • , Edward A. Pham
    • , Benjamin Fram
    • , Aijaz Ahmed
    • , Aaron M. Newman
    • , Jeffrey S. Glenn
    • , Mark M. Davis
    • , Susan M. Kaech
    • , Irving L. Weissman
    •  & Kim J. Hasenkrug
  • Research | | open

    Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely related protective and less protective HLA alleles, and their differential effect on viral control

    • Funsho Ogunshola
    • , Gursev Anmole
    • , Rachel L. Miller
    • , Emily Goering
    • , Thandeka Nkosi
    • , Daniel Muema
    • , Jaclyn Mann
    • , Nasreen Ismail
    • , Denis Chopera
    • , Thumbi Ndung’u
    • , Mark A. Brockman
    •  & Zaza M Ndhlovu
  • Research | | open

    RIG-I and MDA5, are cytosolic restriction factors and receptors for RNA viruses. Here the authors show during KSHV lytic infection that substrates for recognition by RIG-I and MDA5 are misprocessed RNAs derived from noncoding host RNA molecules, suggesting antiviral immunity can be engaged by sensing of misprocessed cellular RNAs.

    • Yang Zhao
    • , Xiang Ye
    • , William Dunker
    • , Yu Song
    •  & John Karijolich
  • Research |

    Neutralizing murine monoclonal antibodies against the Eeastern equine encephalitis virus target the E2 glycoprotein, block infection at a post-attachment stage by inhibiting viral membrane fusion and protect mice from lethal challenge.

    • Arthur S. Kim
    • , S. Kyle Austin
    • , Christina L. Gardner
    • , Adam Zuiani
    • , Douglas S. Reed
    • , Derek W. Trobaugh
    • , Chengqun Sun
    • , Katherine Basore
    • , Lauren E. Williamson
    • , James E. Crowe Jr.
    • , Mark K. Slifka
    • , Daved H. Fremont
    • , William B. Klimstra
    •  & Michael S. Diamond
    Nature Microbiology 4, 187-197

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