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The viral host response is the process by which a host interacts with and responds to viruses that it encounters. It includes various mechanisms, such as immune mechanisms that are elicited in an attempt to eliminate the virus or halt its growth.
The cGAS-STING pathway is a DNA sensing mechanism that enables response to viral infection by inducing type 1 interferon expression. Here the authors show a mechanism by which the deubiquitinating enzyme USP13 prevents STING from enabling response to virus.
ZIKV-specific and ZIKV/DENV cross-reactive human HLA epitopes are identified in naïve and DENV-immune mice, revealing altered immunodominance in the DENV-immune setting and a protective role for epitope-specific CD8+ T cells against ZIKV.
Flaviviruses stimulate cross-reactive immune responses that may reduce or exacerbate manifestations of subsequent flavivirus infection. Recent work demonstrates that cross-reactive T cells protect against Zika in HLA transgenic mice, a key step in the development of safe and effective vaccines.
The quest to improve influenza vaccines is aided by research into the immune response that they generate. Two recent studies have focused their attention on the specificities of antibodies induced after vaccination with conventional inactivated influenza vaccines.