Viral genetics

Definition

Viral genetics is the study of the mechanisms of heritable information in viruses, including genome structure, replication and genetic change. Disease causing viruses are of particular interest, however geneticists also use viruses to help understand fundamental mechanisms of molecular genetics.

Latest Research and Reviews

  • Research |

    LysM, the lysis protein of the Escherichia coli levivirus M, represents a new ‘protein antibiotic’ that interferes with the synthesis of peptidoglycan by inhibiting lipid II flipping.

    • Karthik R. Chamakura
    • , Lok-To Sham
    • , Rebecca M. Davis
    • , Lorna Min
    • , Hongbaek Cho
    • , Natividad Ruiz
    • , Thomas G. Bernhardt
    •  & Ry Young
    Nature Microbiology 2, 1480–1484
  • Research |

    Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.

    • Nathan D. Grubaugh
    • , Jason T. Ladner
    • , Moritz U. G. Kraemer
    • , Gytis Dudas
    • , Amanda L. Tan
    • , Karthik Gangavarapu
    • , Michael R. Wiley
    • , Stephen White
    • , Julien Thézé
    • , Diogo M. Magnani
    • , Karla Prieto
    • , Daniel Reyes
    • , Andrea M. Bingham
    • , Lauren M. Paul
    • , Refugio Robles-Sikisaka
    • , Glenn Oliveira
    • , Darryl Pronty
    • , Carolyn M. Barcellona
    • , Hayden C. Metsky
    • , Mary Lynn Baniecki
    • , Kayla G. Barnes
    • , Bridget Chak
    • , Catherine A. Freije
    • , Adrianne Gladden-Young
    • , Andreas Gnirke
    • , Cynthia Luo
    • , Bronwyn MacInnis
    • , Christian B. Matranga
    • , Daniel J. Park
    • , James Qu
    • , Stephen F. Schaffner
    • , Christopher Tomkins-Tinch
    • , Kendra L. West
    • , Sarah M. Winnicki
    • , Shirlee Wohl
    • , Nathan L. Yozwiak
    • , Joshua Quick
    • , Joseph R. Fauver
    • , Kamran Khan
    • , Shannon E. Brent
    • , Robert C. Reiner Jr
    • , Paola N. Lichtenberger
    • , Michael J. Ricciardi
    • , Varian K. Bailey
    • , David I. Watkins
    • , Marshall R. Cone
    • , Edgar W. Kopp IV
    • , Kelly N. Hogan
    • , Andrew C. Cannons
    • , Reynald Jean
    • , Andrew J. Monaghan
    • , Robert F. Garry
    • , Nicholas J. Loman
    • , Nuno R. Faria
    • , Mario C. Porcelli
    • , Chalmers Vasquez
    • , Elyse R. Nagle
    • , Derek A. T. Cummings
    • , Danielle Stanek
    • , Andrew Rambaut
    • , Mariano Sanchez-Lockhart
    • , Pardis C. Sabeti
    • , Leah D. Gillis
    • , Scott F. Michael
    • , Trevor Bedford
    • , Oliver G. Pybus
    • , Sharon Isern
    • , Gustavo Palacios
    •  & Kristian G. Andersen
    Nature 546, 401–405
  • Protocols |

    This multiplex PCR enrichment protocol enables sequencing of Zika and other viral genomes of low abundance from clinical samples using the Illumina platform, or the portable MinION sequencer, facilitating direct application in field situations.

    • Joshua Quick
    • , Nathan D Grubaugh
    • , Steven T Pullan
    • , Ingra M Claro
    • , Andrew D Smith
    • , Karthik Gangavarapu
    • , Glenn Oliveira
    • , Refugio Robles-Sikisaka
    • , Thomas F Rogers
    • , Nathan A Beutler
    • , Dennis R Burton
    • , Lia Laura Lewis-Ximenez
    • , Jaqueline Goes de Jesus
    • , Marta Giovanetti
    • , Sarah C Hill
    • , Allison Black
    • , Trevor Bedford
    • , Miles W Carroll
    • , Marcio Nunes
    • , Luiz Carlos Alcantara Jr.
    • , Ester C Sabino
    • , Sally A Baylis
    • , Nuno R Faria
    • , Matthew Loose
    • , Jared T Simpson
    • , Oliver G Pybus
    • , Kristian G Andersen
    •  & Nicholas J Loman
    Nature Protocols 12, 1261–1276

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