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A vacuole is a membrane-bound organelle found in plant and fungal cells. Vacuoles have a variety of cellular functions, including storage, sequestration and structural support. Vacuoles also have important roles in autophagy and degradation of cellular contents.
Microbial pathogens secrete effector proteins into host cells to affect cellular functions. Here, the authors use a yeast-based screen to study around 200 effectors from six bacterial species, showing that over 30% of them interact with the eukaryotic plasma membrane or intracellular organelles.
The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. Here the authors show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites.
Coccolithophores are unicellular marine algae that produce calcitic
particles inside their cells. Here the authors study cells of the dominant
coccolithophore Emiliania huxleyi and identify an intracellular compartment that
is filled with high concentrations of a disordered form of calcium.