Urology

  • Article
    | Open Access

    Urinary tract infections (UTIs) are associated with changes in the gut microbiome. Here, the authors evaluate the relationship between the gut microbiome and development of UTI in kidney transplant patients and show that uropathogenic gut abundance might represent a risk factor for development of bacteriuria and UTI.

    • Matthew Magruder
    • , Adam N. Sholi
    • , Catherine Gong
    • , Lisa Zhang
    • , Emmanuel Edusei
    • , Jennifer Huang
    • , Shady Albakry
    • , Michael J. Satlin
    • , Lars F. Westblade
    • , Carl Crawford
    • , Darshana M. Dadhania
    • , Michelle Lubetzky
    • , Ying Taur
    • , Eric Littman
    • , Lilan Ling
    • , Philip Burnham
    • , Iwijn De Vlaminck
    • , Eric Pamer
    • , Manikkam Suthanthiran
    •  & John Richard Lee
  • Article
    | Open Access

    LRIG1 is a tumour suppressor in several cancers. Here, the authors show that androgen receptor directly transactivates LRIG1 which then antagonises ERBB signalling and c-Myc expression to inhibit prostate tumorigenesis.

    • Qiuhui Li
    • , Bigang Liu
    • , Hsueh-Ping Chao
    • , Yibing Ji
    • , Yue Lu
    • , Rashid Mehmood
    • , Collene Jeter
    • , Taiping Chen
    • , John R. Moore
    • , Wenqian Li
    • , Can Liu
    • , Kiera Rycaj
    • , Amanda Tracz
    • , Jason Kirk
    • , Tammy Calhoun-Davis
    • , Jie Xiong
    • , Qu Deng
    • , Jiaoti Huang
    • , Barbara A. Foster
    • , Abhiram Gokhale
    • , Xin Chen
    •  & Dean G. Tang
  • Article
    | Open Access

    Detecting genomic abnormalities in metastatic castration-resistant prostate cancer (mCRPC) may impact clinical treatment. Here, the authors present whole-genome sequencing of metastatic biopsies from 197 mCRPC patients, highlighting the landscape of microsatellite stability, homologous repair deficiency, and other genomic subgroups.

    • Lisanne F. van Dessel
    • , Job van Riet
    • , Minke Smits
    • , Yanyun Zhu
    • , Paul Hamberg
    • , Michiel S. van der Heijden
    • , Andries M. Bergman
    • , Inge M. van Oort
    • , Ronald de Wit
    • , Emile E. Voest
    • , Neeltje Steeghs
    • , Takafumi N. Yamaguchi
    • , Julie Livingstone
    • , Paul C. Boutros
    • , John W. M. Martens
    • , Stefan Sleijfer
    • , Edwin Cuppen
    • , Wilbert Zwart
    • , Harmen J. G. van de Werken
    • , Niven Mehra
    •  & Martijn P. Lolkema
  • Article
    | Open Access

    The biology of the urothelium has been difficult to study given the lack of methods to propagate these cells. Here, the authors generate mouse urothelial organoids derived from bladder urothelial cells with high CD49f/ITGA6 and define what regulates urothelium differentiation, which is PPARγ, EGFR and Notch signalling.

    • Catarina P. Santos
    • , Eleonora Lapi
    • , Jaime Martínez de Villarreal
    • , Laura Álvaro-Espinosa
    • , Asunción Fernández-Barral
    • , Antonio Barbáchano
    • , Orlando Domínguez
    • , Ashley M. Laughney
    • , Diego Megías
    • , Alberto Muñoz
    •  & Francisco X. Real
  • Article
    | Open Access

    More than 170 genetic loci have been linked to prostate cancer risk, primarily based on genome-wide association studies (GWAS) in European population. Here, the authors performed a GWAS on a Japanese cohort of prostate cancer patients, finding 12 new susceptibility loci, and identifying a polygenic risk for Japanese prostate cancer.

    • Ryo Takata
    • , Atsushi Takahashi
    • , Masashi Fujita
    • , Yukihide Momozawa
    • , Edward J. Saunders
    • , Hiroki Yamada
    • , Kazuhiro Maejima
    • , Kaoru Nakano
    • , Yuichiro Nishida
    • , Asahi Hishida
    • , Keitaro Matsuo
    • , Kenji Wakai
    • , Taiki Yamaji
    • , Norie Sawada
    • , Motoki Iwasaki
    • , Shoichiro Tsugane
    • , Makoto Sasaki
    • , Atsushi Shimizu
    • , Kozo Tanno
    • , Naoko Minegishi
    • , Kichiya Suzuki
    • , Koichi Matsuda
    • , Michiaki Kubo
    • , Johji Inazawa
    • , Shin Egawa
    • , Christopher A. Haiman
    • , Osamu Ogawa
    • , Wataru Obara
    • , Yoichiro Kamatani
    • , Shusuke Akamatsu
    •  & Hidewaki Nakagawa
  • Article
    | Open Access

    HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.

    • Wen Jing Sim
    • , Prasanna Vasudevan Iyengar
    • , Dilraj Lama
    • , Sarah Kit Leng Lui
    • , Hsien Chun Ng
    • , Lior Haviv-Shapira
    • , Eytan Domany
    • , Dennis Kappei
    • , Tuan Zea Tan
    • , Azad Saei
    • , Patrick William Jaynes
    • , Chandra Shekhar Verma
    • , Alan Prem Kumar
    • , Mathieu Rouanne
    • , Hong Koo Ha
    • , Camelia Radulescu
    • , Peter ten Dijke
    • , Pieter Johan Adam Eichhorn
    •  & Jean Paul Thiery
  • Article
    | Open Access

    Prostate cancer progression may be enhanced by a high-fat diet. Here the authors show that a diet high in saturated fats enhance the MYC-driven transcriptional program, a feature that independently predicts prostate cancer progression and death.

    • David P. Labbé
    • , Giorgia Zadra
    • , Meng Yang
    • , Jaime M. Reyes
    • , Charles Y. Lin
    • , Stefano Cacciatore
    • , Ericka M. Ebot
    • , Amanda L. Creech
    • , Francesca Giunchi
    • , Michelangelo Fiorentino
    • , Habiba Elfandy
    • , Sudeepa Syamala
    • , Edward D. Karoly
    • , Mohammed Alshalalfa
    • , Nicholas Erho
    • , Ashley Ross
    • , Edward M. Schaeffer
    • , Ewan A. Gibb
    • , Mandeep Takhar
    • , Robert B. Den
    • , Jonathan Lehrer
    • , R. Jeffrey Karnes
    • , Stephen J. Freedland
    • , Elai Davicioni
    • , Daniel E. Spratt
    • , Leigh Ellis
    • , Jacob D. Jaffe
    • , Anthony V. DʼAmico
    • , Philip W. Kantoff
    • , James E. Bradner
    • , Lorelei A. Mucci
    • , Jorge E. Chavarro
    • , Massimo Loda
    •  & Myles Brown
  • Article
    | Open Access

    The identification of synthetic essential genes of PTEN is of therapeutic potential for PTEN-deficient prostate cancers. Here, the authors show that ARID4B is a synthetic essential gene in these cancers in which deficiency of PTEN prompts the AKT-ARID4B feedback loop required for activation of the PI3K-AKT signaling pathway.

    • Ray-Chang Wu
    • , In-Chi Young
    • , Yu-Fang Chen
    • , Sung-Ting Chuang
    • , Antoun Toubaji
    •  & Mei-Yi Wu
  • Article
    | Open Access

    Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.

    • Melusine Bleu
    • , Swann Gaulis
    • , Rui Lopes
    • , Kathleen Sprouffske
    • , Verena Apfel
    • , Sjoerd Holwerda
    • , Marco Pregnolato
    • , Umut Yildiz
    • , Valentina Cordoʹ
    • , Antonella F. M. Dost
    • , Judith Knehr
    • , Walter Carbone
    • , Felix Lohmann
    • , Charles Y. Lin
    • , James E. Bradner
    • , Audrey Kauffmann
    • , Luca Tordella
    • , Guglielmo Roma
    •  & Giorgio G. Galli
  • Article
    | Open Access

    Recurrent urinary tract infections occur in ~ 25% of women. Here, Beatson and colleagues use whole genome sequencing to track the dynamics of an E. coli ST131 clone in a single patient over a 5-year period. This study provides unique insights into pathogen evolution during recurrent urinary infection.

    • Brian M. Forde
    • , Leah W. Roberts
    • , Minh-Duy Phan
    • , Kate M. Peters
    • , Brittany A. Fleming
    • , Colin W. Russell
    • , Sara M. Lenherr
    • , Jeremy B. Myers
    • , Adam P. Barker
    • , Mark A. Fisher
    • , Teik-Min Chong
    • , Wai-Fong Yin
    • , Kok-Gan Chan
    • , Mark A. Schembri
    • , Matthew A. Mulvey
    •  & Scott A. Beatson
  • Article
    | Open Access

    Iatrogenic injury of the ureters is a feared complication of laparoscopic abdominal surgery. Here the authors present the NIR fluorophore ZW800-1 as an intraoperative imaging agent for ureter mapping, showing its safety, pharmacokinetic properties, and efficacy in healthy volunteers and patients undergoing abdominopelvic surgery.

    • Kim S. de Valk
    • , Henricus J. Handgraaf
    • , Marion M. Deken
    • , Babs G. Sibinga Mulder
    • , Adrianus R. Valentijn
    • , Anton G. Terwisscha van Scheltinga
    • , Joeri Kuil
    • , Michiel J. van Esdonk
    • , Jaap Vuijk
    • , Rob F. Bevers
    • , Koen C. Peeters
    • , Fabian A. Holman
    • , John V. Frangioni
    • , Jacobus Burggraaf
    •  & Alexander L. Vahrmeijer
  • Article
    | Open Access

    In prostate cancer, investigating aberrant gene expression may shed light on disease etiology. Here, the authors imputed expression transcriptome-wide for 233,955 European ancestry men, discovering and replicating the associations between prostatic expression for select genes and prostate cancer risk, including the highly prevalent gene fusion partner TMPRSS2. The authors furthermore integrate diverse functional genomic datasets to interpret the epigenetic mechanisms by which the implicated risk variants and genes modulate disease risk.

    • Nima C. Emami
    • , Linda Kachuri
    • , Travis J. Meyers
    • , Rajdeep Das
    • , Joshua D. Hoffman
    • , Thomas J. Hoffmann
    • , Donglei Hu
    • , Jun Shan
    • , Felix Y. Feng
    • , Elad Ziv
    • , Stephen K. Van Den Eeden
    •  & John S. Witte
  • Article
    | Open Access

    Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology.

    • Brian D. Robinson
    • , Panagiotis J. Vlachostergios
    • , Bhavneet Bhinder
    • , Weisi Liu
    • , Kailyn Li
    • , Tyler J. Moss
    • , Rohan Bareja
    • , Kyung Park
    • , Peyman Tavassoli
    • , Joanna Cyrta
    • , Scott T. Tagawa
    • , David M. Nanus
    • , Himisha Beltran
    • , Ana M. Molina
    • , Francesca Khani
    • , Juan Miguel Mosquera
    • , Evanguelos Xylinas
    • , Shahrokh F. Shariat
    • , Douglas S. Scherr
    • , Mark A. Rubin
    • , Seth P. Lerner
    • , Surena F. Matin
    • , Olivier Elemento
    •  & Bishoy M. Faltas
  • Article
    | Open Access

    The induction of neuroendocrine differentiation occurs in enzalutamide treated castration resistant prostate cancer. Here, the authors show that lncRNA-21 mediates enzalutamide induced neuroendocrine differentiation through EZH2/STAT axis and EZH2 inhibition suppresses this differentiation.

    • Jie Luo
    • , Keliang Wang
    • , Shuyuan Yeh
    • , Yin Sun
    • , Liang Liang
    • , Yao Xiao
    • , Wanhai Xu
    • , Yuanjie Niu
    • , Liang Cheng
    • , Sankar N. Maity
    • , Runze Jiang
    •  & Chawnshang Chang
  • Article
    | Open Access

    Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating  these collagen III/CD167a-driven metastatic foci.

    • Yu-Cheng Lee
    • , Antonina V. Kurtova
    • , Jing Xiao
    • , Fotis Nikolos
    • , Kazukuni Hayashi
    • , Zoe Tramel
    • , Antrix Jain
    • , Fengju Chen
    • , Mithil Chokshi
    • , Ciaran Lee
    • , Gang Bao
    • , Xiang Zhang
    • , Jianjun Shen
    • , Qianxing Mo
    • , Sung Yun Jung
    • , David Rowley
    •  & Keith Syson Chan
  • Article
    | Open Access

    Clear-cell carcinomas are aggressive tumours characterised by high accumulation of lipids and glycogen. Here, the authors report that these cancers have a common vulnerability to GPX4 inhibition-induced ferroptosis and using CRISPR screen and lipodomic profiling, they identify HIF-2α- HILPDA axis promotes ferroptosis via enrichment of PUFA lipids.

    • Yilong Zou
    • , Michael J. Palte
    • , Amy A. Deik
    • , Haoxin Li
    • , John K. Eaton
    • , Wenyu Wang
    • , Yuen-Yi Tseng
    • , Rebecca Deasy
    • , Maria Kost-Alimova
    • , Vlado Dančík
    • , Elizaveta S. Leshchiner
    • , Vasanthi S. Viswanathan
    • , Sabina Signoretti
    • , Toni K. Choueiri
    • , Jesse S. Boehm
    • , Bridget K. Wagner
    • , John G. Doench
    • , Clary B. Clish
    • , Paul A. Clemons
    •  & Stuart L. Schreiber
  • Article
    | Open Access

    Clear cell renal cell carcinoma (ccRCC) is a urogenital cancer with a well-defined genetic landscape. Here, the authors analyse the clonal architecture of ccRCC patients from three populations, and find prognostic subtypes linked to immune infiltrates and clonal architecture.

    • Yi Huang
    • , Jiayin Wang
    • , Peilin Jia
    • , Xiangchun Li
    • , Guangsheng Pei
    • , Changxi Wang
    • , Xiaodong Fang
    • , Zhongming Zhao
    • , Zhiming Cai
    • , Xin Yi
    • , Song Wu
    •  & Baifeng Zhang
  • Article
    | Open Access

    Super enhancers are frequently involved in the dysregulation of gene expression in cancer. Here, in kidney cancer, a super enhancer is shown to drive the expression of KLF6, which alters the expression of lipid metabolism genes and promotes tumorigenesis.

    • Saiful E. Syafruddin
    • , Paulo Rodrigues
    • , Erika Vojtasova
    • , Saroor A. Patel
    • , M. Nazhif Zaini
    • , Johanna Burge
    • , Anne Y. Warren
    • , Grant D. Stewart
    • , Tim Eisen
    • , Dóra Bihary
    • , Shamith A. Samarajiwa
    •  & Sakari Vanharanta
  • Article
    | Open Access

    Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.

    • Song Wu
    • , Tong Ou
    • , Nianzeng Xing
    • , Jiang Lu
    • , Shengqing Wan
    • , Changxi Wang
    • , Xi Zhang
    • , Feiya Yang
    • , Yi Huang
    •  & Zhiming Cai
  • Article
    | Open Access

    ER stress and UPR are implicated in various cancers. Here, the authors show that one of the canonical UPR pathways, IRE1α-XBP1 regulates c-MYC signaling to promote prostate tumorigenesis, and pharmacological inhibition of IRE1α with MKC8866 inhibits prostate cancer growth and synergizes with clinically used prostate cancer drugs.

    • Xia Sheng
    • , Hatice Zeynep Nenseth
    • , Su Qu
    • , Omer F. Kuzu
    • , Turid Frahnow
    • , Lukas Simon
    • , Stephanie Greene
    • , Qingping Zeng
    • , Ladan Fazli
    • , Paul S. Rennie
    • , Ian G. Mills
    • , Håvard Danielsen
    • , Fabian Theis
    • , John B. Patterson
    • , Yang Jin
    •  & Fahri Saatcioglu
  • Article
    | Open Access

    miR-205 is known to have context-dependent tumor suppressive or oncogenic roles. Here, the authors report the host gene of miR-205, MIR205HG as a nuclear lincRNA that maintains the basal identity of prostate cell and prevents luminal cell differentiation via the repression of interferon responsive genes.

    • Valentina Profumo
    • , Barbara Forte
    • , Stefano Percio
    • , Federica Rotundo
    • , Valentina Doldi
    • , Elena Ferrari
    • , Nicola Fenderico
    • , Matteo Dugo
    • , Dario Romagnoli
    • , Matteo Benelli
    • , Riccardo Valdagni
    • , Diletta Dolfini
    • , Nadia Zaffaroni
    •  & Paolo Gandellini
  • Article
    | Open Access

    Neuroendocrine prostate cancer (NEPC) is characterized by loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, resulting in resistance to AR-targeted therapy. Here they report ONECUT2 to drive NEPC tumorigenesis via regulation of hypoxia signaling and tumor hypoxia, and find hypoxia directed therapy to be effective in NEPC.

    • Haiyang Guo
    • , Xinpei Ci
    • , Musaddeque Ahmed
    • , Junjie Tony Hua
    • , Fraser Soares
    • , Dong Lin
    • , Loredana Puca
    • , Aram Vosoughi
    • , Hui Xue
    • , Estelle Li
    • , Peiran Su
    • , Sujun Chen
    • , Tran Nguyen
    • , Yi Liang
    • , Yuzhe Zhang
    • , Xin Xu
    • , Jing Xu
    • , Anjali V. Sheahan
    • , Wail Ba-Alawi
    • , Si Zhang
    • , Osman Mahamud
    • , Ravi N. Vellanki
    • , Martin Gleave
    • , Robert G. Bristow
    • , Benjamin Haibe-Kains
    • , John T. Poirier
    • , Charles M. Rudin
    • , Ming-Sound Tsao
    • , Bradly G. Wouters
    • , Ladan Fazli
    • , Felix Y. Feng
    • , Leigh Ellis
    • , Theo van der Kwast
    • , Alejandro Berlin
    • , Marianne Koritzinsky
    • , Paul C. Boutros
    • , Amina Zoubeidi
    • , Himisha Beltran
    • , Yuzhuo Wang
    •  & Housheng Hansen He
  • Article
    | Open Access

    Activation of the PPARγ/RXRα pathway in luminal bladder cancers has mainly been linked to PPARG gene amplifications and activating point mutations in RXRα. Here, the authors identify recurrent PPARγ mutations with similar effects and elucidate the structural basis for this mutational PPARγ activation.

    • Natacha Rochel
    • , Clémentine Krucker
    • , Laure Coutos-Thévenot
    • , Judit Osz
    • , Ruiyun Zhang
    • , Elodie Guyon
    • , Wayne Zita
    • , Séverin Vanthong
    • , Oscar Alba Hernandez
    • , Maxime Bourguet
    • , Kays Al Badawy
    • , Florent Dufour
    • , Carole Peluso-Iltis
    • , Syrine Heckler-Beji
    • , Annick Dejaegere
    • , Aurélie Kamoun
    • , Aurélien de Reyniès
    • , Yann Neuzillet
    • , Sandra Rebouissou
    • , Claire Béraud
    • , Hervé Lang
    • , Thierry Massfelder
    • , Yves Allory
    • , Sarah Cianférani
    • , Roland H. Stote
    • , François Radvanyi
    •  & Isabelle Bernard-Pierrot
  • Article
    | Open Access

    Identifying cell intrinsic mechanisms promoting metastasis are necessary to develop new cancer therapeutics. Here they do cross-species computational analysis and identify nuclear receptor binding SET domain Protein 2 (NSD2) as a driver of prostate cancer metastasis.

    • Alvaro Aytes
    • , Arianna Giacobbe
    • , Antonina Mitrofanova
    • , Katia Ruggero
    • , Joanna Cyrta
    • , Juan Arriaga
    • , Luis Palomero
    • , Sonia Farran-Matas
    • , Mark A. Rubin
    • , Michael M. Shen
    • , Andrea Califano
    •  & Cory Abate-Shen
  • Article
    | Open Access

    TRIM24 is stabilized in SPOP-mutated prostate cancers, but the regulation of TRIM24 in wild-type prostate cancers is unknown. Here, the authors show that TRIM28 interacts with TRIM24 to prevent SPOP-mediated ubiquitination of TRIM24 and enhances TRIM24 and AR signaling to induce prostate cancer tumorigenesis.

    • Ka-wing Fong
    • , Jonathan C. Zhao
    • , Bing Song
    • , Bin Zheng
    •  & Jindan Yu
  • Article
    | Open Access

    Prostate cancer often develops resistance to androgen receptor (AR) targeting drugs. Here, the authors show that, under conditions of hypoxia, AR inhibition via enzalutamide increases the expression of the glycolytic enzyme phosphoglucose isomerase (GPI) promoting a metabolic rewiring that allows the cells to survive, and consistent GPI inhibition restores sensitivity to enzalutamide.

    • Hao Geng
    • , Changhui Xue
    • , Janet Mendonca
    • , Xiao-Xin Sun
    • , Qiong Liu
    • , Patrick N. Reardon
    • , Yingxiao Chen
    • , Kendrick Qian
    • , Vivian Hua
    • , Alice Chen
    • , Freddy Pan
    • , Julia Yuan
    • , Sang Dang
    • , Tomasz M. Beer
    • , Mu-Shui Dai
    • , Sushant K. Kachhap
    •  & David Z. Qian
  • Article
    | Open Access

    The Androgen Receptor (AR) is the main driver of prostate cancer and functions in conjunction with chromatin modifications. Here, the authors comprehensively profile 100 primary prostate carcinomas by sequencing RNA transcripts in combination with ChIP-sequencing for AR and the active histone marks H3K27ac, H3K4me3 and repressive mark H3K27me3.

    • Suzan Stelloo
    • , Ekaterina Nevedomskaya
    • , Yongsoo Kim
    • , Karianne Schuurman
    • , Eider Valle-Encinas
    • , João Lobo
    • , Oscar Krijgsman
    • , Daniel Simon Peeper
    • , Seiwon Laura Chang
    • , Felix Yi-Chung Feng
    • , Lodewyk Frederik Ary Wessels
    • , Rui Henrique
    • , Carmen Jerónimo
    • , Andries Marinus Bergman
    •  & Wilbert Zwart
  • Article
    | Open Access

    The AR-V7 isoform is associated with anti-androgen drug resistance in prostate cancer. Here, the authors show that AR-V7 protein stability is regulated by HSP70/STUB1 complex-mediated proteostasis which confers drug resistance in late stage prostate cancer. Inhibition of HSP70 re-sensitizes resistant cells to enzalutamide therapy.

    • Chengfei Liu
    • , Wei Lou
    • , Joy C. Yang
    • , Liangren Liu
    • , Cameron M. Armstrong
    • , Alan P. Lombard
    • , Ruining Zhao
    • , Onika D. V. Noel
    • , Clifford G. Tepper
    • , Hong-Wu Chen
    • , Marc Dall’Era
    • , Christopher P. Evans
    •  & Allen C. Gao
  • Article
    | Open Access

    Neuroendocrine prostate cancers are very difficult to treat and often arise after androgen-deprivation therapy. Here the authors show that ADT activates CREB that acts by increasing EZH2 activity to promote neuroendocrine differentiation in prostate cancer, providing alternative avenues for therapy.

    • Yan Zhang
    • , Dayong Zheng
    • , Ting Zhou
    • , Haiping Song
    • , Mohit Hulsurkar
    • , Ning Su
    • , Ying Liu
    • , Zheng Wang
    • , Long Shao
    • , Michael Ittmann
    • , Martin Gleave
    • , Huanxing Han
    • , Feng Xu
    • , Wangjun Liao
    • , Hongbo Wang
    •  & Wenliang Li
  • Article
    | Open Access

    The functional significance of the observed heterogeneity of androgen receptor (AR) expression in prostate cancer is unknown. Here the authors show AR expression heterogeneity is associated with distinct castration/enzalutamide responses and identify BCL-2 as a potential therapeutic target in castration-resistant prostate cancer.

    • Qiuhui Li
    • , Qu Deng
    • , Hsueh-Ping Chao
    • , Xin Liu
    • , Yue Lu
    • , Kevin Lin
    • , Bigang Liu
    • , Gregory W. Tang
    • , Dingxiao Zhang
    • , Amanda Tracz
    • , Collene Jeter
    • , Kiera Rycaj
    • , Tammy Calhoun-Davis
    • , Jiaoti Huang
    • , Mark A. Rubin
    • , Himisha Beltran
    • , Jianjun Shen
    • , Gurkamal Chatta
    • , Igor Puzanov
    • , James L. Mohler
    • , Jianmin Wang
    • , Ruizhe Zhao
    • , Jason Kirk
    • , Xin Chen
    •  & Dean G. Tang
  • Article
    | Open Access

    Urinary tract infections are one of the most common infections in humans. Here, the authors use urinary cell-free DNA (cfDNA) to comprehensively monitor host and pathogen dynamics in bacterial and viral urinary tract infections, and show that it is a versatile analyte for monitoring urinary tract infections.

    • Philip Burnham
    • , Darshana Dadhania
    • , Michael Heyang
    • , Fanny Chen
    • , Lars F. Westblade
    • , Manikkam Suthanthiran
    • , John Richard Lee
    •  & Iwijn De Vlaminck
  • Article
    | Open Access

    Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

    • Tokhir Dadaev
    • , Edward J. Saunders
    • , Paul J. Newcombe
    • , Ezequiel Anokian
    • , Daniel A. Leongamornlert
    • , Mark N. Brook
    • , Clara Cieza-Borrella
    • , Martina Mijuskovic
    • , Sarah Wakerell
    • , Ali Amin Al Olama
    • , Fredrick R. Schumacher
    • , Sonja I. Berndt
    • , Sara Benlloch
    • , Mahbubl Ahmed
    • , Chee Goh
    • , Xin Sheng
    • , Zhuo Zhang
    • , Kenneth Muir
    • , Koveela Govindasami
    • , Artitaya Lophatananon
    • , Victoria L. Stevens
    • , Susan M. Gapstur
    • , Brian D. Carter
    • , Catherine M. Tangen
    • , Phyllis Goodman
    • , Ian M. Thompson Jr.
    • , Jyotsna Batra
    • , Suzanne Chambers
    • , Leire Moya
    • , Judith Clements
    • , Lisa Horvath
    • , Wayne Tilley
    • , Gail Risbridger
    • , Henrik Gronberg
    • , Markus Aly
    • , Tobias Nordström
    • , Paul Pharoah
    • , Nora Pashayan
    • , Johanna Schleutker
    • , Teuvo L. J. Tammela
    • , Csilla Sipeky
    • , Anssi Auvinen
    • , Demetrius Albanes
    • , Stephanie Weinstein
    • , Alicja Wolk
    • , Niclas Hakansson
    • , Catharine West
    • , Alison M. Dunning
    • , Neil Burnet
    • , Lorelei Mucci
    • , Edward Giovannucci
    • , Gerald Andriole
    • , Olivier Cussenot
    • , Géraldine Cancel-Tassin
    • , Stella Koutros
    • , Laura E. Beane Freeman
    • , Karina Dalsgaard Sorensen
    • , Torben Falck Orntoft
    • , Michael Borre
    • , Lovise Maehle
    • , Eli Marie Grindedal
    • , David E. Neal
    • , Jenny L. Donovan
    • , Freddie C. Hamdy
    • , Richard M. Martin
    • , Ruth C. Travis
    • , Tim J. Key
    • , Robert J. Hamilton
    • , Neil E. Fleshner
    • , Antonio Finelli
    • , Sue Ann Ingles
    • , Mariana C. Stern
    • , Barry Rosenstein
    • , Sarah Kerns
    • , Harry Ostrer
    • , Yong-Jie Lu
    • , Hong-Wei Zhang
    • , Ninghan Feng
    • , Xueying Mao
    • , Xin Guo
    • , Guomin Wang
    • , Zan Sun
    • , Graham G. Giles
    • , Melissa C. Southey
    • , Robert J. MacInnis
    • , Liesel M. FitzGerald
    • , Adam S. Kibel
    • , Bettina F. Drake
    • , Ana Vega
    • , Antonio Gómez-Caamaño
    • , Laura Fachal
    • , Robert Szulkin
    • , Martin Eklund
    • , Manolis Kogevinas
    • , Javier Llorca
    • , Gemma Castaño-Vinyals
    • , Kathryn L. Penney
    • , Meir Stampfer
    • , Jong Y. Park
    • , Thomas A. Sellers
    • , Hui-Yi Lin
    • , Janet L. Stanford
    • , Cezary Cybulski
    • , Dominika Wokolorczyk
    • , Jan Lubinski
    • , Elaine A. Ostrander
    • , Milan S. Geybels
    • , Børge G. Nordestgaard
    • , Sune F. Nielsen
    • , Maren Weisher
    • , Rasmus Bisbjerg
    • , Martin Andreas Røder
    • , Peter Iversen
    • , Hermann Brenner
    • , Katarina Cuk
    • , Bernd Holleczek
    • , Christiane Maier
    • , Manuel Luedeke
    • , Thomas Schnoeller
    • , Jeri Kim
    • , Christopher J. Logothetis
    • , Esther M. John
    • , Manuel R. Teixeira
    • , Paula Paulo
    • , Marta Cardoso
    • , Susan L. Neuhausen
    • , Linda Steele
    • , Yuan Chun Ding
    • , Kim De Ruyck
    • , Gert De Meerleer
    • , Piet Ost
    • , Azad Razack
    • , Jasmine Lim
    • , Soo-Hwang Teo
    • , Daniel W. Lin
    • , Lisa F. Newcomb
    • , Davor Lessel
    • , Marija Gamulin
    • , Tomislav Kulis
    • , Radka Kaneva
    • , Nawaid Usmani
    • , Chavdar Slavov
    • , Vanio Mitev
    • , Matthew Parliament
    • , Sandeep Singhal
    • , Frank Claessens
    • , Steven Joniau
    • , Thomas Van den Broeck
    • , Samantha Larkin
    • , Paul A. Townsend
    • , Claire Aukim-Hastie
    • , Manuela Gago-Dominguez
    • , Jose Esteban Castelao
    • , Maria Elena Martinez
    • , Monique J. Roobol
    • , Guido Jenster
    • , Ron H. N. van Schaik
    • , Florence Menegaux
    • , Thérèse Truong
    • , Yves Akoli Koudou
    • , Jianfeng Xu
    • , Kay-Tee Khaw
    • , Lisa Cannon-Albright
    • , Hardev Pandha
    • , Agnieszka Michael
    • , Andrzej Kierzek
    • , Stephen N. Thibodeau
    • , Shannon K. McDonnell
    • , Daniel J. Schaid
    • , Sara Lindstrom
    • , Constance Turman
    • , Jing Ma
    • , David J. Hunter
    • , Elio Riboli
    • , Afshan Siddiq
    • , Federico Canzian
    • , Laurence N. Kolonel
    • , Loic Le Marchand
    • , Robert N. Hoover
    • , Mitchell J. Machiela
    • , Peter Kraft
    • , Margaret Cook
    • , Alison Thwaites
    • , Michelle Guy
    • , Ian Whitmore
    • , Angela Morgan
    • , Cyril Fisher
    • , Steve Hazel
    • , Naomi Livni
    • , Amanda Spurdle
    • , Srilakshmi Srinivasan
    • , Mary-Anne Kedda
    • , Joanne Aitken
    • , Robert Gardiner
    • , Vanessa Hayes
    • , Lisa Butler
    • , Renea Taylor
    • , Trina Yeadon
    • , Allison Eckert
    • , Pamela Saunders
    • , Anne-Maree Haynes
    • , Melissa Papargiris
    • , Paula Kujala
    • , Kirsi Talala
    • , Teemu Murtola
    • , Kimmo Taari
    • , David Dearnaley
    • , Gill Barnett
    • , Søren Bentzen
    • , Rebecca Elliott
    • , Hardeep Ranu
    • , Belynda Hicks
    • , Aurelie Vogt
    • , Amy Hutchinson
    • , Angela Cox
    • , Michael Davis
    • , Paul Brown
    • , Anne George
    • , Gemma Marsden
    • , Athene Lane
    • , Sarah J. Lewis
    • , Clare Berry
    • , Girish S. Kulkarni
    • , Ants Toi
    • , Andrew Evans
    • , Alexandre R. Zlotta
    • , Theodorus H. van der Kwast
    • , Takashi Imai
    • , Shiro Saito
    • , Jacek Marzec
    • , Guangwen Cao
    • , Ji Lin
    • , Jin Ling
    • , Meiling Li
    • , Shan-Chao Zhao
    • , Guoping Ren
    • , Yongwei Yu
    • , Yudong Wu
    • , Ji Wu
    • , Bo Zhou
    • , Yangling Zhang
    • , Jie Li
    • , Weiyang He
    • , Jianming Guo
    • , John Pedersen
    • , John L. Hopper
    • , Roger Milne
    • , Aleksandra Klim
    • , Ana Carballo
    • , Ramón Lobato-Busto
    • , Paula Peleteiro
    • , Patricia Calvo
    • , Miguel Aguado
    • , José Manuel Ruiz-Dominguez
    • , Lluís Cecchini
    • , Lourdes Mengual
    • , Antonio Alcaraz
    • , Mariona Bustamante
    • , Esther Gracia-Lavedan
    • , Trinidad Dierssen-Sotos
    • , Ines Gomez-Acebo
    • , Julio Pow-Sang
    • , Hyun Park
    • , Babu Zachariah
    • , Wojciech Kluzniak
    • , Suzanne Kolb
    • , Peter Klarskov
    • , Christa Stegmaier
    • , Walther Vogel
    • , Kathleen Herkommer
    • , Philipp Bohnert
    • , Sofia Maia
    • , Maria P. Silva
    • , Sofie De Langhe
    • , Hubert Thierens
    • , Meng H. Tan
    • , Aik T. Ong
    • , Zeljko Kastelan
    • , Elenko Popov
    • , Darina Kachakova
    • , Atanaska Mitkova
    • , Aleksandrina Vlahova
    • , Tihomir Dikov
    • , Svetlana Christova
    • , Angel Carracedo
    • , Christopher Bangma
    • , F. H. Schroder
    • , Sylvie Cenee
    • , Brigitte Tretarre
    • , Xavier Rebillard
    • , Claire Mulot
    • , Marie Sanchez
    • , Jan Adolfsson
    • , Par Stattin
    • , Jan-Erik Johansson
    • , Carin Cavalli-Bjoerkman
    • , Ami Karlsson
    • , Michael Broms
    • , Huihai Wu
    • , Lori Tillmans
    • , Shaun Riska
    • , Matthew Freedman
    • , Fredrik Wiklund
    • , Stephen Chanock
    • , Brian E. Henderson
    • , Douglas F. Easton
    • , Christopher A. Haiman
    • , Rosalind A. Eeles
    • , David V. Conti
    •  & Zsofia Kote-Jarai
  • Article
    | Open Access

    Wnt11 has been shown to play a role in invasion and metastasis of prostate cancer. Here the authors show that in prostate cancer cells Wnt11 signals through the Fzd8 receptor and report an interaction between Fzd8 and TGF-β receptors regulating the transcription of a subset of TGF-beta genes.

    • Virginia Murillo-Garzón
    • , Irantzu Gorroño-Etxebarria
    • , Malin Åkerfelt
    • , Mikael Christer Puustinen
    • , Lea Sistonen
    • , Matthias Nees
    • , James Carton
    • , Jonathan Waxman
    •  & Robert M. Kypta
  • Article
    | Open Access

    Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream effector of the androgen receptor and create a feed forward loop that increases the therapeutic efficacy.

    • Michael R. McDevitt
    • , Daniel L. J. Thorek
    • , Takeshi Hashimoto
    • , Tatsuo Gondo
    • , Darren R. Veach
    • , Sai Kiran Sharma
    • , Teja Muralidhar Kalidindi
    • , Diane S. Abou
    • , Philip A. Watson
    • , Bradley J. Beattie
    • , Oskar Vilhemsson Timmermand
    • , Sven-Erik Strand
    • , Jason S. Lewis
    • , Peter T. Scardino
    • , Howard I. Scher
    • , Hans Lilja
    • , Steven M. Larson
    •  & David Ulmert
  • Article
    | Open Access

    CP1 is an uropathogenic Escherichia coli previously shown to promote inflammation and progression to prostate cancer. Here the authors show that in the context of a fully developed prostate cancer, CP1 promotes T cell infiltration into the tumour and increases the efficacy of anti-PD1 immunotherapy.

    • Jonathan F. Anker
    • , Anum F. Naseem
    • , Hanlin Mok
    • , Anthony J. Schaeffer
    • , Sarki A. Abdulkadir
    •  & Praveen Thumbikat
  • Article
    | Open Access

    The female bladder seems to harbor a poorly characterized indigenous microbiota. Here, the authors isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women, generating a culture collection representing two thirds of the bacterial diversity within the samples.

    • Krystal Thomas-White
    • , Samuel C. Forster
    • , Nitin Kumar
    • , Michelle Van Kuiken
    • , Catherine Putonti
    • , Mark D. Stares
    • , Evann E. Hilt
    • , Travis K. Price
    • , Alan J. Wolfe
    •  & Trevor D. Lawley
  • Article
    | Open Access

    Understanding of molecular events in cancer requires proteome-level characterisation. Here, proteome profiling of patient samples representing primary and progressed prostate cancer enables the authors to identify pathway alterations that are not reflected at the genomic and transcriptomic levels.

    • Leena Latonen
    • , Ebrahim Afyounian
    • , Antti Jylhä
    • , Janika Nättinen
    • , Ulla Aapola
    • , Matti Annala
    • , Kati K. Kivinummi
    • , Teuvo T. L. Tammela
    • , Roger W. Beuerman
    • , Hannu Uusitalo
    • , Matti Nykter
    •  & Tapio Visakorpi
  • Article
    | Open Access

    Asthenozoospermia is a major cause of male infertility, and multiple morphological abnormalities of the flagella (MMAF) is a particularly severe form. Here, using whole-exome sequencing of 78 MMAF patients, the authors identify mutations in two WDR proteins, CFAP43 and CFAP44, and confirm that these proteins are required for flagellogenesis in mouse and Trypanosoma brucei.

    • Charles Coutton
    • , Alexandra S. Vargas
    • , Amir Amiri-Yekta
    • , Zine-Eddine Kherraf
    • , Selima Fourati Ben Mustapha
    • , Pauline Le Tanno
    • , Clémentine Wambergue-Legrand
    • , Thomas Karaouzène
    • , Guillaume Martinez
    • , Serge Crouzy
    • , Abbas Daneshipour
    • , Seyedeh Hanieh Hosseini
    • , Valérie Mitchell
    • , Lazhar Halouani
    • , Ouafi Marrakchi
    • , Mounir Makni
    • , Habib Latrous
    • , Mahmoud Kharouf
    • , Jean-François Deleuze
    • , Anne Boland
    • , Sylviane Hennebicq
    • , Véronique Satre
    • , Pierre-Simon Jouk
    • , Nicolas Thierry-Mieg
    • , Beatrice Conne
    • , Denis Dacheux
    • , Nicolas Landrein
    • , Alain Schmitt
    • , Laurence Stouvenel
    • , Patrick Lorès
    • , Elma El Khouri
    • , Serge P. Bottari
    • , Julien Fauré
    • , Jean-Philippe Wolf
    • , Karin Pernet-Gallay
    • , Jessica Escoffier
    • , Hamid Gourabi
    • , Derrick R. Robinson
    • , Serge Nef
    • , Emmanuel Dulioust
    • , Raoudha Zouari
    • , Mélanie Bonhivers
    • , Aminata Touré
    • , Christophe Arnoult
    •  & Pierre F. Ray
  • Article
    | Open Access

    The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth of castration-resistant prostate cancer tumors.

    • Sen Zhu
    • , Dongyu Zhao
    • , Lin Yan
    • , Weihua Jiang
    • , Jung-Sun Kim
    • , Bingnan Gu
    • , Qipeng Liu
    • , Rui Wang
    • , Bo Xia
    • , Jonathan C. Zhao
    • , Gang Song
    • , Wenyi Mi
    • , Rong-Fu Wang
    • , Xiaobing Shi
    • , Hung-Ming Lam
    • , Xuesen Dong
    • , Jindan Yu
    • , Kaifu Chen
    •  & Qi Cao
  • Article
    | Open Access

    Alterations in the MAPK pathway are common in cancers, yet mutations are rarely found in patients. Here the authors find genomic amplifications of the PPP1CA gene in advanced and metastatic prostate cancer and identify a role for this phosphatase in the positive regulation of ERK signalling.

    • Ming Chen
    • , Lixin Wan
    • , Jiangwen Zhang
    • , Jinfang Zhang
    • , Lourdes Mendez
    • , John G. Clohessy
    • , Kelsey Berry
    • , Joshua Victor
    • , Qing Yin
    • , Yuan Zhu
    • , Wenyi Wei
    •  & Pier Paolo Pandolfi
  • Article
    | Open Access

    The impact of cisplatin-based chemotherapy on tumor genomes is complex. Here, the authors study matched pre- and post-chemotherapy primary samples in muscle-invasive bladder cancer, finding a cisplatin-based mutational signature, and highlighting the impact of intratumor heterogeneity on survival.

    • David Liu
    • , Philip Abbosh
    • , Daniel Keliher
    • , Brendan Reardon
    • , Diana Miao
    • , Kent Mouw
    • , Amaro Weiner-Taylor
    • , Stephanie Wankowicz
    • , Garam Han
    • , Min Yuen Teo
    • , Catharine Cipolla
    • , Jaegil Kim
    • , Gopa Iyer
    • , Hikmat Al-Ahmadie
    • , Essel Dulaimi
    • , David Y. T. Chen
    • , R. Katherine Alpaugh
    • , Jean Hoffman-Censits
    • , Levi A. Garraway
    • , Gad Getz
    • , Scott L. Carter
    • , Joaquim Bellmunt
    • , Elizabeth R. Plimack
    • , Jonathan E. Rosenberg
    •  & Eliezer M. Van Allen
  • Article
    | Open Access

    Mutations in VHL have been linked to clear cell renal cancer, but the molecular mechanisms involved remain unclear. Here the authors generate a mouse model closely mimicking the human disease and show that VHL loss induces DNA replication stress that is rescued by the concomitant loss of PBRM1 permitting transformation.

    • Judit Espana-Agusti
    • , Anne Warren
    • , Su Kit Chew
    • , David J. Adams
    •  & Athena Matakidou
  • Article
    | Open Access

    Cell-based hormone replacement therapy (cHRT) may be an alternative therapy to pharmacological (p)HRT. Here, the authors show that implanted 3D bioengineered ovarian constructs of granulosa and theca cells in ovariectomized rats recapitulate native cell interactions and improve efficacy compared to similar doses of pHRT.

    • Sivanandane Sittadjody
    • , Justin M. Saul
    • , John P. McQuilling
    • , Sunyoung Joo
    • , Thomas C. Register
    • , James J. Yoo
    • , Anthony Atala
    •  & Emmanuel C. Opara
  • Article
    | Open Access

    Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into the mitochondrion resulting in reduced FA beta oxidation.

    • Weinan Du
    • , Luchang Zhang
    • , Adina Brett-Morris
    • , Brittany Aguila
    • , Janos Kerner
    • , Charles L. Hoppel
    • , Michelle Puchowicz
    • , Dolors Serra
    • , Laura Herrero
    • , Brian I. Rini
    • , Steven Campbell
    •  & Scott M. Welford
  • Article
    | Open Access

    Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells.

    • Ana Filipa Gonçalves
    • , Mojca Adlesic
    • , Simone Brandt
    • , Tomas Hejhal
    • , Sabine Harlander
    • , Lukas Sommer
    • , Olga Shakhova
    • , Peter J. Wild
    •  & Ian J. Frew
  • Article
    | Open Access

    Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers. Here the authors show that acetylated H2A.Z is redistributed at cancer neo-enhancers and regulates the activity of specific enhancers of cancer-related genes.

    • Fátima Valdés-Mora
    • , Cathryn M. Gould
    • , Yolanda Colino-Sanguino
    • , Wenjia Qu
    • , Jenny Z. Song
    • , Kylie M. Taylor
    • , Fabian A. Buske
    • , Aaron L. Statham
    • , Shalima S. Nair
    • , Nicola J. Armstrong
    • , James G. Kench
    • , Kenneth M. L. Lee
    • , Lisa G. Horvath
    • , Minru Qiu
    • , Alexei Ilinykh
    • , Nicole S. Yeo-Teh
    • , David Gallego-Ortega
    • , Clare Stirzaker
    •  & Susan J. Clark
  • Article
    | Open Access

    Identifying actionable components in castration–resistant prostate cancer (CRPC) is critical for the development of effective treatments. Here, the authors show that the inhibition of the redox-protective protein TRX1 decreases the growth of CRPC cells through the regulation of ROS levels, p53 and androgen receptor expression.

    • Govindi J. Samaranayake
    • , Clara I. Troccoli
    • , Mai Huynh
    • , Rolando D. Z. Lyles
    • , Karen Kage
    • , Andrew Win
    • , Vishalakshi Lakshmanan
    • , Deukwoo Kwon
    • , Yuguang Ban
    • , Steven Xi Chen
    • , Enrique Rodriguez Zarco
    • , Merce Jorda
    • , Kerry L. Burnstein
    •  & Priyamvada Rai
  • Article
    | Open Access

    The incidence of renal cell carcinoma is higher in males than in females due to the different androgen receptor signaling but the molecular mechanisms behind this gender bias are unclear. Here the authors show how androgen receptor expression influences the metastatic route through the regulation of miR-185 and VEGF isoforms.

    • Qingbo Huang
    • , Yin Sun
    • , Xin Ma
    • , Yu Gao
    • , Xintao Li
    • , Yuanjie Niu
    • , Xu Zhang
    •  & Chawnshang Chang
  • Article
    | Open Access

    In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

    • Julia F. Hopkins
    • , Veronica Y. Sabelnykova
    • , Joachim Weischenfeldt
    • , Ronald Simon
    • , Jennifer A. Aguiar
    • , Rached Alkallas
    • , Lawrence E. Heisler
    • , Junyan Zhang
    • , John D. Watson
    • , Melvin L. K. Chua
    • , Michael Fraser
    • , Francesco Favero
    • , Chris Lawerenz
    • , Christoph Plass
    • , Guido Sauter
    • , John D. McPherson
    • , Theodorus van der Kwast
    • , Jan Korbel
    • , Thorsten Schlomm
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Article
    | Open Access

    Treatment of prostate cancer, especially in its advanced stage, is still challenging; therefore, strategies to prevent metastatic dissemination are of great interest. Here the authors reveal a crucial role for liver X receptors in suppressing prostate carcinogenesis and metastatic progression in PTEN-null tumors.

    • Anthony Alioui
    • , Julie Dufour
    • , Valerio Leoni
    • , Anke Loregger
    • , Martina Moeton
    • , Luigi Iuliano
    • , Chiara Zerbinati
    • , Amandine Septier
    • , Pierre Val
    • , Allan Fouache
    • , Vincenzo Russo
    • , David H. Volle
    • , Jean-Marc A. Lobaccaro
    • , Noam Zelcer
    •  & Silvère Baron