Urological manifestations articles within Nature Communications

Featured

• Article
  27 March 2024 | Open Access

  Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI

  Catheter-associated urinary tract infections can often lead to secondary bloodstream infections, and catheter-induced bladder inflammation. In this work, authors utilise murine models to probe defective fibrinolysis drives extravascular fibrin formation, potentially predisposing hosts to severe CAUTI.

  • Jonathan J. Molina
  • , Kurt N. Kohler
  •  & Ana L. Flores-Mireles

• Article
  19 July 2023 | Open Access

  A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease

  Kidney stone disease causes significant morbidity and increases in health care utilization. Here, the authors define the spatial molecular landscape and specific pathways contributing to stone-mediated injury in the human renal papilla and identify associated urinary biomarkers.

  • Victor Hugo Canela
  • , William S. Bowen
  •  & Tarek M. El-Achkar

• Article
  28 August 2020 | Open Access

  Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology

  Ketamine is a general anesthetic that is used also as an anti-depressant, but its use is associated with cystitis. Here, the authors show that ketamine is an antagonist of the Cav1.2 channel in bladder smooth muscle cells, that ablation of this channel in mice mimics the cystitis induced by ketamine, and show that this effect can be abrogated by an agonist of this ion channel.

  • Huan Chen
  • , David H. Vandorpe
  •  & Weiqun Yu