Urogenital models

Definition

Urogenital models are experimental systems that recreate aspects of human urogenital development, function or disease. They include animal models of gonad development and urogenital disease.

Latest Research and Reviews

  • Reviews |

    3D organoids are valuable tools for increasing understanding of disease biology. In this Review, the authors describe how successful application of organoids into urological cancer research can further our understanding of these diseases and provide preclinical cancer models to aid precision medicine.

    • Shangqian Wang
    • , Dong Gao
    •  & Yu Chen
  • Research | | open

    • Millissia Ben Maamar
    • , Laurianne Lesné
    • , Kristin Hennig
    • , Christèle Desdoits-Lethimonier
    • , Karen R. Kilcoyne
    • , Isabelle Coiffec
    • , Antoine D. Rolland
    • , Cécile Chevrier
    • , David M. Kristensen
    • , Vincent Lavoué
    • , Jean-Philippe Antignac
    • , Bruno Le Bizec
    • , Nathalie Dejucq-Rainsford
    • , Rod T. Mitchell
    • , Séverine Mazaud-Guittot
    •  & Bernard Jégou
  • Protocols |

    This protocol describes stepwise differentiation of human pluripotent stem cells into 3D kidney organoids that contain segmented nephrons connected to collecting ducts, which are surrounded by renal interstitial cells and an endothelial network.

    • Minoru Takasato
    • , Pei X Er
    • , Han S Chiu
    •  & Melissa H Little
    Nature Protocols 11, 1681–1692
  • Reviews |

    Simulation has become widely accepted as a supplementary method of training in urological skills, with the greatest number of procedure-specific models and subsequent validation studies carried out in the field of endourology. Skills simulators have been created for laparoscopic and robot-assisted surgery, but only a limited number of validated models are available for open procedures. In this Review, Aydin and colleagues discuss the various modalities of simulators available to urologists and suggest a curriculum for structured surgical training.

    • Abdullatif Aydin
    • , Nicholas Raison
    • , Muhammad Shamim Khan
    • , Prokar Dasgupta
    •  & Kamran Ahmed
  • Protocols |

    This protocol describes a strategy for generating 3D prostate organoid cultures from healthy mouse and human prostate cells (either bulk or FAC-sorted single luminal and basal cells), metastatic prostate cancer lesions and circulating tumor cells.

    • Jarno Drost
    • , Wouter R Karthaus
    • , Dong Gao
    • , Else Driehuis
    • , Charles L Sawyers
    • , Yu Chen
    •  & Hans Clevers
    Nature Protocols 11, 347–358

News and Comment