Ulcerative colitis

Ulcerative colitis is an inflammatory bowel disease that is characterized by chronic inflammation of the colon. The direct cause of the disease is unknown, but patients are commonly treated with anti-inflammatory drugs.

Latest Research and Reviews

  • Research |

    Tissue-resident memory T cells (TRM cells) have well-described functions in the protective response to infectious agents. Neurath and colleagues demonstrate that intestinal TRM cells can also have key pathogenic roles in inflammatory bowel disease.

    • Sebastian Zundler
    • , Emily Becker
    • , Marta Spocinska
    • , Monique Slawik
    • , Loreto Parga-Vidal
    • , Regina Stark
    • , Maximilian Wiendl
    • , Raja Atreya
    • , Timo Rath
    • , Moritz Leppkes
    • , Kai Hildner
    • , Rocío López-Posadas
    • , Sören Lukassen
    • , Arif B. Ekici
    • , Clemens Neufert
    • , Imke Atreya
    • , Klaas P. J. M. van Gisbergen
    •  & Markus F. Neurath
    Nature Immunology 20, 288-300
  • Research | | open

    The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis.

    • Yael Haberman
    • , Rebekah Karns
    • , Phillip J. Dexheimer
    • , Melanie Schirmer
    • , Judith Somekh
    • , Ingrid Jurickova
    • , Tzipi Braun
    • , Elizabeth Novak
    • , Laura Bauman
    • , Margaret H. Collins
    • , Angela Mo
    • , Michael J. Rosen
    • , Erin Bonkowski
    • , Nathan Gotman
    • , Alison Marquis
    • , Mason Nistel
    • , Paul A. Rufo
    • , Susan S. Baker
    • , Cary G. Sauer
    • , James Markowitz
    • , Marian D. Pfefferkorn
    • , Joel R. Rosh
    • , Brendan M. Boyle
    • , David R. Mack
    • , Robert N. Baldassano
    • , Sapana Shah
    • , Neal S. Leleiko
    • , Melvin B. Heyman
    • , Anne M. Grifiths
    • , Ashish S. Patel
    • , Joshua D. Noe
    • , Bruce J. Aronow
    • , Subra Kugathasan
    • , Thomas D. Walters
    • , Greg Gibson
    • , Sonia Davis Thomas
    • , Kevin Mollen
    • , Shai Shen-Orr
    • , Curtis Huttenhower
    • , Ramnik J. Xavier
    • , Jeffrey S. Hyams
    •  & Lee A. Denson
  • Research | | open

    • Aina E. Fossum Moen
    • , Jonas Christoffer Lindstrøm
    • , Tone Møller Tannæs
    • , Simen Vatn
    • , Petr Ricanek
    • , Morten H. Vatn
    • , Jørgen Jahnsen
    • , Anna B. Frengen
    • , Fredrik A. Dahl
    • , Panpan You
    • , Janne Sølvernes
    • , Gunn S. Ekeland
    • , Trond E. Detlie
    • , Christine Olbjørn
    • , Kate R. O’Leary
    • , Nicholas T. Ventham
    • , Nicholas A. Kennedy
    • , Rahul Kalla
    • , Alex Adams
    • , Hazel E. Drummond
    • , Ray Boyapati
    • , Elaine R. Nimmo
    • , David C. Wilson
    • , Jack Satsangi
    • , Simon C. Heath
    • , Marta Gut
    • , Angelika Merkel
    • , Monica Bayes
    • , Ivo G. Gut
    • , Åsa V. Keita
    • , Johan D. Söderholm
    • , Henrik Hjortswang
    • , Adam Carstens
    • , Daniel Bergemalm
    • , Jonas Halfvarson
    • , Erik Andersson
    • , Mårten Lindqvist
    • , Dirk Repsilber
    • , Marieke Pierik
    • , Daisy Jonkers
    • , Fernando Gomollón
    • , Mauro D’Amato
    • , Leif Törkvist
    • , Fredrik Hjelm
    • , Mats Gullberg
    • , Niklas Nordberg
    • , Anette Ocklind
    • , Erik Pettersson
    • , Daniel Ekman
    • , Mikael Sundell
    • , Eddie Modig
    • , Ferdinando Bonfiglio
    • , Anne-Clémence Veillard
    • , Renaud Schoemans
    • , Dominique Poncelet
    • , Céline Sabatel
    • , Torbjørn Lindahl
    • , Ewa Ciemniejewska
    • , Christina Casén
    • , Charles Lees
    • , Colin L. Noble
    • , Ian Arnott
    • , Gwo-Tzer Ho
    •  & Alan G. Shand

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