Tumour virus infections

Tumour virus infections are caused by oncogenic DNA or RNA viruses. They can cause cancer by two different processes: directly through the expression of viral proteins that disrupt tissue cells and result in their transformation; and indirectly through mutation of the host cell DNA through viral integration (also known as insertional mutagenesis).

Latest Research and Reviews

  • Reviews |

    Kaposi sarcoma is a rare cancer that typically presents with multiple pigmented skin lesions, but may take an aggressive course characterised by lesion ulceration, oedema and visceral organ involvement. This Primer describes the epidemiology, clinical features, cellular mechanisms and management of the main forms of Kaposi sarcoma.

    • Ethel Cesarman
    • , Blossom Damania
    • , Susan E. Krown
    • , Jeffrey Martin
    • , Mark Bower
    •  & Denise Whitby
  • Research | | open

    • Keisuke Kataoka
    • , Hiroaki Miyoshi
    • , Seiji Sakata
    • , Akito Dobashi
    • , Lucile Couronné
    • , Yasunori Kogure
    • , Yasuharu Sato
    • , Kenji Nishida
    • , Yuka Gion
    • , Yuichi Shiraishi
    • , Hiroko Tanaka
    • , Kenichi Chiba
    • , Yosaku Watatani
    • , Nobuyuki Kakiuchi
    • , Yusuke Shiozawa
    • , Tetsuichi Yoshizato
    • , Kenichi Yoshida
    • , Hideki Makishima
    • , Masashi Sanada
    • , Masahiro Onozawa
    • , Takanori Teshima
    • , Yumiko Yoshiki
    • , Tadao Ishida
    • , Kenshi Suzuki
    • , Kazuyuki Shimada
    • , Akihiro Tomita
    • , Motohiro Kato
    • , Yasunori Ota
    • , Koji Izutsu
    • , Ayako Demachi-Okamura
    • , Yoshiki Akatsuka
    • , Satoru Miyano
    • , Tadashi Yoshino
    • , Philippe Gaulard
    • , Olivier Hermine
    • , Kengo Takeuchi
    • , Koichi Ohshima
    •  & Seishi Ogawa
    Leukemia, 1-13
  • Research | | open

    Focal amplifications are prevalent in many cancer genomes. Here, the authors present AmpliconArchitect (AA), a computational tool for reconstructing their architecture, and reveal an extrachromosomal origin for focal amplifications, including hybrid human-virus elements in HPV-mediated cancers.

    • Viraj Deshpande
    • , Jens Luebeck
    • , Nam-Phuong D. Nguyen
    • , Mehrdad Bakhtiari
    • , Kristen M. Turner
    • , Richard Schwab
    • , Hannah Carter
    • , Paul S. Mischel
    •  & Vineet Bafna
  • Research |

    Genome sequencing of fractionated T-, B- and natural killer cells from patients with chronic active Epstein–Barr virus (EBV) infection sheds light on the nature of the EBV-infected progenitor and suggests a link between intragenic EBV deletions and EBV-associated neoplastic proliferations.

    • Yusuke Okuno
    • , Takayuki Murata
    • , Yoshitaka Sato
    • , Hideki Muramatsu
    • , Yoshinori Ito
    • , Takahiro Watanabe
    • , Tatsuya Okuno
    • , Norihiro Murakami
    • , Kenichi Yoshida
    • , Akihisa Sawada
    • , Masami Inoue
    • , Keisei Kawa
    • , Masao Seto
    • , Koichi Ohshima
    • , Yuichi Shiraishi
    • , Kenichi Chiba
    • , Hiroko Tanaka
    • , Satoru Miyano
    • , Yohei Narita
    • , Masahiro Yoshida
    • , Fumi Goshima
    • , Jun-ichi Kawada
    • , Tetsuya Nishida
    • , Hitoshi Kiyoi
    • , Seiichi Kato
    • , Shigeo Nakamura
    • , Satoko Morishima
    • , Tetsushi Yoshikawa
    • , Shigeyoshi Fujiwara
    • , Norio Shimizu
    • , Yasushi Isobe
    • , Masaaki Noguchi
    • , Atsushi Kikuta
    • , Keiji Iwatsuki
    • , Yoshiyuki Takahashi
    • , Seiji Kojima
    • , Seishi Ogawa
    •  & Hiroshi Kimura

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