Tumour vaccines

Definition

A tumour vaccine is an agent used for cancer therapy or cancer prevention that elicits an immune response and induces protective immunity against specific molecules (antigens) expressed on tumour cells. There are currently no vaccines that can prevent cancer from developing, but some therapeutic tumour vaccines have shown promise in patients with selected cancers.

Latest Research and Reviews

  • Research | | open

    Viruses trigger potent cytotoxic T cell responses, whereas anti-tumour immunity has been difficult to establish. Here the authors engineer a replicating viral delivery system for tumour-associated antigens, which induces alarmin release, innate activation and protective anti-tumour immunity in mice.

    • Sandra M. Kallert
    • , Stephanie Darbre
    • , Weldy V. Bonilla
    • , Mario Kreutzfeldt
    • , Nicolas Page
    • , Philipp Müller
    • , Matthias Kreuzaler
    • , Min Lu
    • , Stéphanie Favre
    • , Florian Kreppel
    • , Max Löhning
    • , Sanjiv A. Luther
    • , Alfred Zippelius
    • , Doron Merkler
    •  & Daniel D. Pinschewer
  • Research | | open

    Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.

    • Zhenyu Zhong
    • , Yougang Zhai
    • , Ping Bu
    • , Shivanee Shah
    •  & Liang Qiao
  • Research | | open

    Dendritic cells are antigen-presenting cells consisting of distinct subsets originating from different lineages. Here, the authors identify the subsets of dendritic cells populating the tumour tissue in both mice and humans and find they have opposing functions in regulating the anti-tumour immune response.

    • Damya Laoui
    • , Jiri Keirsse
    • , Yannick Morias
    • , Eva Van Overmeire
    • , Xenia Geeraerts
    • , Yvon Elkrim
    • , Mate Kiss
    • , Evangelia Bolli
    • , Qods Lahmar
    • , Dorine Sichien
    • , Jens Serneels
    • , Charlotte L. Scott
    • , Louis Boon
    • , Patrick De Baetselier
    • , Massimiliano Mazzone
    • , Martin Guilliams
    •  & Jo A. Van Ginderachter
  • Reviews |

    This Review summarizes immune evasion mechanisms that limit the therapeutic efficacy of cancer vaccines. The authors discuss how improving vaccine design and using vaccines in combination with other anticancer therapies can boost treatment efficacy in patients with established cancers.

    • Sjoerd H. van der Burg
    • , Ramon Arens
    • , Ferry Ossendorp
    • , Thorbald van Hall
    •  & Cornelis J. M. Melief
    Nature Reviews Cancer 16, 219–233

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