Tumour immunology

Tumour immunology describes the interaction between cells of the immune system with tumour cells. Understanding these interactions is important for the development of new therapies for cancer treatment.

Latest Research and Reviews

  • Research | | open

    Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti-tumour immunity.

    • Shawn P. Kubli
    • , Larsen Vornholz
    • , Gordon Duncan
    • , Wenjing Zhou
    • , Parameswaran Ramachandran
    • , Jerome Fortin
    • , Maureen Cox
    • , SeongJun Han
    • , Robert Nechanitzky
    • , Duygu Nechanitzky
    • , Bryan E. Snow
    • , Lisa Jones
    • , Wanda Y. Li
    • , Jillian Haight
    • , Andrew Wakeham
    • , Mark R. Bray
    •  & Tak W. Mak
  • Research |

    • Andrew C. Scott
    • , Friederike Dündar
    • , Paul Zumbo
    • , Smita S. Chandran
    • , Christopher A. Klebanoff
    • , Mojdeh Shakiba
    • , Prerak Trivedi
    • , Laura Menocal
    • , Heather Appleby
    • , Steven J. Camara
    • , Dmitriy Zamarin
    • , Tyler Walther
    • , Alexandra C. Snyder
    • , Matthew R. Femia
    • , Elizabeth A. Comen
    • , Hannah Y. Wen
    • , Matthew D. Hellmann
    • , Niroshana Anandasabapathy
    • , Yong Liu
    • , Nasser K. Altorki
    • , Peter Lauer
    • , Olivier Levy
    • , Michael Glickman
    • , Jonathan Kaye
    • , Doron Betel
    • , Mary Philip
    •  & Andrea Schietinger
    Nature, 1-8
  • Research | | open

    Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cells in an organotypic model.

    • Dieter Henrik Heiland
    • , Vidhya M. Ravi
    • , Simon P. Behringer
    • , Jan Hendrik Frenking
    • , Julian Wurm
    • , Kevin Joseph
    • , Nicklas W. C. Garrelfs
    • , Jakob Strähle
    • , Sabrina Heynckes
    • , Jürgen Grauvogel
    • , Pamela Franco
    • , Irina Mader
    • , Matthias Schneider
    • , Anna-Laura Potthoff
    • , Daniel Delev
    • , Ulrich G. Hofmann
    • , Christian Fung
    • , Jürgen Beck
    • , Roman Sankowski
    • , Marco Prinz
    •  & Oliver Schnell
  • Research | | open

    Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.

    • Min Thura
    • , Abdul Qader Al-Aidaroos
    • , Abhishek Gupta
    • , Cheng Ean Chee
    • , Soo Chin Lee
    • , Kam Man Hui
    • , Jie Li
    • , Yeoh Khay Guan
    • , Wei Peng Yong
    • , Jimmy So
    • , Wee Joo Chng
    • , Chin Hin Ng
    • , Jianbiao Zhou
    • , Ling Zhi Wang
    • , John Shyi Peng Yuen
    • , Henry Sun Sien Ho
    • , Sim Mei Yi
    • , Edmund Chiong
    • , Su Pin Choo
    • , Joanne Ngeow
    • , Matthew Chau Hsien Ng
    • , Clarinda Chua
    • , Eugene Shen Ann Yeo
    • , Iain Bee Huat Tan
    • , Joel Xuan En Sng
    • , Nicholas Yan Zhi Tan
    • , Jean Paul Thiery
    • , Boon Cher Goh
    •  & Qi Zeng

News and Comment

  • Research Highlights |

    Christoph Hess describes a 1984 paper by Barry Marshall and Robin Warren that proposed that bacteria might be a key factor in chronic gastritis.

    • Christoph Hess
  • Comments and Opinion |

    In this Viewpoint article, we asked four scientists working on the cancer microbiome to provide their opinions on the current state of the field, where the research is heading and the challenges of implementing this field for clinical utility.

    • Eran Elinav
    • , Wendy S. Garrett
    • , Giorgio Trinchieri
    •  & Jennifer Wargo
  • Research Highlights |

    Di Pilato et al. selectively modulated the function of regulatory T (Treg) cells in tumours by targeting the CARMA1–BCL10–MALT1 (CBM) signalosome complex in only a fraction of Treg cells and showed that this was sufficient to impede tumour growth and prime the tumour microenvironment for immune checkpoint blockade.

    • Anna Dart
  • Research Highlights |

    Yang et al. identified a patient with metastatic head and neck squamous cell carcinoma who exhibited complete response to immunotherapy despite a low mutational burden, and demonstrated that gene fusions were a source of neoantigens in this patient and others.

    • Jordan Hindson
  • Research Highlights |

    The response to anti-PD1 therapy depends on the expression of CXCR3 ligands by dendritic cells in the tumour, which promote the proliferation and activation of intratumoural CD8+ T cells.

    • Kirsty Minton