Tuberculosis

Tuberculosis (TB) is an infectious disease caused by strains of bacteria known as mycobacteria. The disease most commonly affects the lungs and can be fatal if not treated. However, most infected individuals show no disease symptoms. One third of the world’s population is thought to have been infected with TB.

Latest Research and Reviews

News and Comment

  • News and Views |

    Vaccination with the tuberculosis (TB) vaccine Bacillus Calmette–Guérin (BCG) into the lungs of Rhesus macaques induces specific, local immune responses that delay infection in some animals and completely prevent it in others while protecting against TB disease.

    • Thomas J. Scriba
    •  & Elisa Nemes
    Nature Medicine 25, 199-201
  • News and Views |

    The discovery of CD153 as a novel driver of T-cell-mediated host defence against Mycobacterium tuberculosis infection advances our understanding of the requirements for protective immunity. Future investigation of CD153 as a potential correlate of tuberculosis immunity could open new avenues for vaccine design.

    • Sara B. Cohen
    •  & Kevin B. Urdahl
    Nature Microbiology 3, 1194-1195
  • News and Views |

    The H445Y mutation in the β-subunit of RNA polymerase in Mycobacterium tuberculosis causes resistance to the antibiotic rifampicin and changes mycobacterial lipid composition. Infection with rpoB H445Y results in metabolic shifts that allow the bacteria to bypass a key host inflammatory response.

    • Yu-Xiang Chen
    •  & Babak Javid
    Nature Microbiology 3, 1078-1079