tRNAs

Transfer RNAs (tRNAs) are a type of non-coding ribonucleic acid (ncRNA) that carry specific amino acids and recognize unique messenger RNA (mRNA) sequences. The pairing of a tRNA to its compatible mRNA sequence within the ribosome is the basis for the translation of RNA into protein.

Latest Research and Reviews

  • Research | | open

    The authors present a molecular approach and a software suite for high-throughput sequencing and characterization of microbial tRNA transcripts, which provide unique physiological insights into complex environmental microbes.

    • Michael H. Schwartz
    • , Haipeng Wang
    • , Jessica N. Pan
    • , Wesley C. Clark
    • , Steven Cui
    • , Matthew J. Eckwahl
    • , David W. Pan
    • , Marc Parisien
    • , Sarah M. Owens
    • , Brian L. Cheng
    • , Kristina Martinez
    • , Jinbo Xu
    • , Eugene B. Chang
    • , Tao Pan
    •  & A. Murat Eren
  • Reviews |

    Epigenetic profiling of germline and zygotic genomes has revealed that a fraction of mammalian genomes do not undergo epigenetic reprogramming during early development, highlighting the importance of epigenetic inheritance in animals. Inheritance of histone modifications, tRNA fragments and microRNAs can affect gene regulation in the offspring; however, in mammals, epigenetic inheritance rarely operates beyond two generations.

    • Ksenia Skvortsova
    • , Nicola Iovino
    •  & Ozren Bogdanović
  • Research | | open

    Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.

    • Marija Kojic
    • , Monika Gaik
    • , Bence Kiska
    • , Anna Salerno-Kochan
    • , Sarah Hunt
    • , Angelo Tedoldi
    • , Sergey Mureev
    • , Alun Jones
    • , Belinda Whittle
    • , Laura A. Genovesi
    • , Christelle Adolphe
    • , Darren L. Brown
    • , Jennifer L. Stow
    • , Kirill Alexandrov
    • , Pankaj Sah
    • , Sebastian Glatt
    •  & Brandon J. Wainwright
  • Research |

    Enzymes that catalyse modifications of wobble uridine 34 tRNA are essential for the survival of melanoma cells that rely on HIF1α-dependent metabolism through codon-dependent regulation of the translation of HIF1A mRNA.

    • Francesca Rapino
    • , Sylvain Delaunay
    • , Florian Rambow
    • , Zhaoli Zhou
    • , Lars Tharun
    • , Pascal De Tullio
    • , Olga Sin
    • , Kateryna Shostak
    • , Sebastian Schmitz
    • , Jolanda Piepers
    • , Bart Ghesquière
    • , Latifa Karim
    • , Benoit Charloteaux
    • , Diane Jamart
    • , Alexandra Florin
    • , Charles Lambert
    • , Andrée Rorive
    • , Guy Jerusalem
    • , Eleonora Leucci
    • , Michael Dewaele
    • , Marc Vooijs
    • , Sebastian A. Leidel
    • , Michel Georges
    • , Marianne Voz
    • , Bernard Peers
    • , Reinhard Büttner
    • , Jean-Christophe Marine
    • , Alain Chariot
    •  & Pierre Close
    Nature 558, 605-609
  • Research |

    ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.

    • My-Nuong Vo
    • , Markus Terrey
    • , Jeong Woong Lee
    • , Bappaditya Roy
    • , James J. Moresco
    • , Litao Sun
    • , Hongjun Fu
    • , Qi Liu
    • , Thomas G. Weber
    • , John R. Yates III
    • , Kurt Fredrick
    • , Paul Schimmel
    •  & Susan L. Ackerman
    Nature 557, 510-515

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