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Transporters are integral-membrane proteins that form a pore within the plasma membrane to allow passage of various types of molecules, including ions, small molecules and proteins. Transporters can act by either facilitated diffusion or active transport.
Engineering of an artificial metabolon complex consisting of an endogenous sugar transporter and a heterologous isomerase couples the uptake of xylose to its downstream reaction, improving ethanol yield and minimizing an undesired side reaction.
Under high-copper conditions, yersiniabactin (Ybt) binds copper (Cu) to prevent toxicity. Ybt is now shown to mediate Cu import under low-Cu conditions through formation of a Cu(II)-Ybt complex resulting in metalation of a Cu-requiring enzyme.
Multidrug efflux pumps significantly contribute for bacteria resistance to antibiotics. Here the authors present the structure of Campylobacter jejuni CmeB pump combined with functional FRET assays to propose a transport mechanism where each CmeB protomers is functionally independent from the trimer.
A recent study identified a host-derived ammonium transporter in the genome of an algal virus that increases the rate of nitrogen uptake by infected cells and changes how the host accesses diverse nitrogen sources during infection.