Transporters

Transporters are integral-membrane proteins that form a pore within the plasma membrane to allow passage of various types of molecules, including ions, small molecules and proteins. Transporters can act by either facilitated diffusion or active transport.

Latest Research and Reviews

News and Comment

  • News and Views |

    Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to maintain health by treatment with NAD precursors, such as nicotinamide mononucleotide (NMN), represent an exciting area of research in aging and age-related diseases. A study in Nature Metabolism provides an answer to the hotly debated yet fundamental question: how NMN actually gets into cells.

    • Lindsay E. Wu
    •  & David A. Sinclair
  • News and Views |

    The prodrug dimethyloxalylglycine (DMOG) is a well-known tool compound used to study hypoxia. New findings reveal that DMOG also inhibits glutamine metabolism and can be exploited to selectively kill some cancer cells, highlighting important caveats when using DMOG for hypoxia studies.

    • Barbara S. Nelson
    • , Daniel M. Kremer
    •  & Costas A. Lyssiotis
  • News and Views |

    Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

    • Lutz Schmitt