Transplantation

Definition

Transplantation is the procedure of transferring a tissue or organ from one individual to another or from one site to another within a single individual. The transplanted tissue or organ replaces damaged or absent tissue, and is functional in the recipient.

Latest Research and Reviews

  • Research | | open

    Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition of its signalling, both genetic and pharmacological, improves mouse and human islet function.

    • Kim Loh
    • , Yan-Chuan Shi
    • , Stacey Walters
    • , Mohammed Bensellam
    • , Kailun Lee
    • , Katsuya Dezaki
    • , Masanori Nakata
    • , Chi Kin Ip
    • , Jeng Yie Chan
    • , Esteban N. Gurzov
    • , Helen E. Thomas
    • , Michaela Waibel
    • , James Cantley
    • , Thomas W. Kay
    • , Toshihiko Yada
    • , D. Ross Laybutt
    • , Shane T. Grey
    •  & Herbert Herzog
  • Reviews |

    Autologous haematopoietic stem cell transplantation has produced striking results in patients with aggressive multiple sclerosis in small trials. In this Review, Muraro et al. provide an overview of the procedure, detail evidence for its high efficacy in multiple sclerosis, and provide recommendations for its clinical use and future trials.

    • Paolo A. Muraro
    • , Roland Martin
    • , Giovanni Luigi Mancardi
    • , Richard Nicholas
    • , Maria Pia Sormani
    •  & Riccardo Saccardi
  • Reviews |

    To ensure suitability for living kidney donation, donor candidates must be thoroughly evaluated. This Review describes current approaches to the assessment of renal function, haematuria, and cardiac risk in living kidney donor candidates as well as strategies to improve efficiency in the evaluation process, focusing on additional investigations that are commonly ordered by transplant centres rather than the minimum initial screening requirements.

    • Ngan N. Lam
    • , Krista L. Lentine
    •  & Amit X. Garg
  • Reviews |

    Advances in genetics and genomics have transformed the field of organ transplantation. Here, the authors review the role of genetic dissimilarities between donor and recipient in transplant tolerance and rejection, and how the identification of genetic variants that predict adverse transplant outcomes can be used for personalized medicine.

    • Joshua Y. C. Yang
    •  & Minnie M. Sarwal
  • Reviews |

    Liver transplantation is the best option for patients with early-stage hepatocellular carcinoma. Here, the authors summarize the outcomes of liver transplantation, novel surgical techniques to increase the pool of donor livers for transplantation and the limitations of current priority policies.

    • Gonzalo Sapisochin
    •  & Jordi Bruix
  • Reviews |

    Islet transplantation can be an effective therapy for patients with type 1 diabetes, but its widespread use is limited by the need for lifelong immunosuppression. Here, Desai and Shea discuss the emerging potential of islet cell encapsulation including new strategies, assess key challenges facing the human translation of this technology and highlight encapsulation devices that have entered the clinic.

    • Tejal Desai
    •  & Lonnie D. Shea

News and Comment