Transplantation

Transplantation is the procedure of transferring a tissue or organ from one individual to another or from one site to another within a single individual. The transplanted tissue or organ replaces damaged or absent tissue, and is functional in the recipient.

Latest Research and Reviews

  • Reviews |

    Corneal dystrophies are bilateral, progressive inherited disorders affecting any part of the cornea. In this Primer, the authors review the different types of corneal dystrophy, their epidemiology, diagnosis and treatment, and discuss novel treatments that are in development.

    • Yu Qiang Soh
    • , Viridiana Kocaba
    • , Jayne S. Weiss
    • , Ula V. Jurkunas
    • , Shigeru Kinoshita
    • , Anthony J. Aldave
    •  & Jodhbir S. Mehta
  • Reviews |

    Few therapies for spinal cord injury (SCI) have successfully reached the clinic, owing to the complex nature of the injury. This Review highlights two potential new multi-target therapeutic strategies for SCI: olfactory mucosa-derived mesenchymal stromal cells and heparan sulfate mimetics.

    • Susan L. Lindsay
    • , George A. McCanney
    • , Alice G. Willison
    •  & Susan C. Barnett
  • Reviews |

    Natural killer (NK) cells have a primordial role in tumour immunosurveillance. Given their potent antitumour activity, therapeutic manipulation of NK cells provides an attractive strategy for cancer treatment. This Review discusses new approaches to activate NK cells, increase their proliferation in vivo and increase their capacity to recognize tumour cells.

    • Noriko Shimasaki
    • , Amit Jain
    •  & Dario Campana
  • Reviews |

    The use of allogeneic chimeric antigen receptor T cells from donors has many potential advantages over autologous approaches, such as immediate availability, standardization and the possibility of redosing or combination. This Review analyses the different sources of T cells and technological approaches to produce optimal allogeneic chimeric antigen receptor T cells with limited potential for graft-versus-host disease and increased persistence.

    • S. Depil
    • , P. Duchateau
    • , S. A. Grupp
    • , G. Mufti
    •  & L. Poirot

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