Transplantation tolerance

Transplantation tolerance is a state in which the immune system of the recipient of a tissue or organ transplantation does not attack the transplanted tissue. Transplantation tolerance is induced by immunosuppression, and prevents rejection of the transplant.

Latest Research and Reviews

  • Reviews |

    Improved understanding of HLAs together with advances in HLA typing and antibody detection techniques have enabled transplantation of sensitized patients. Here, the authors discuss these advances as well as novel approaches to desensitization, immunomodulation and tolerance induction.

    • Robert A. Montgomery
    • , Vasishta S. Tatapudi
    • , Mary S. Leffell
    •  & Andrea A. Zachary
  • Reviews |

    The functions of the complement system are diverse and extend beyond its role in host defence; complement activation is now known to contribute to numerous immunological, inflammatory and age-related conditions, including kidney disorders. Here, John Lambris and colleagues discuss the key activating, regulatory, and effector mechanisms of the complement system. They highlight important crosstalk connections with other regulatory systems, and, with a focus on kidney disease and transplantation, describe the involvement of complement in clinical conditions as well as promising therapeutic approaches.

    • Daniel Ricklin
    • , Edimara S. Reis
    •  & John D. Lambris
  • Research | | open

    Tweaking immune characteristics of donors and recipients could allow for successful cross-species organ transplantation. Here, the authors show that an anti-CD40 antibody therapy of baboons that received heart transplants from genetically modified pigs is key to their long-term survival.

    • Muhammad M. Mohiuddin
    • , Avneesh K. Singh
    • , Philip C. Corcoran
    • , Marvin L. Thomas III
    • , Tannia Clark
    • , Billeta G. Lewis
    • , Robert F. Hoyt
    • , Michael Eckhaus
    • , Richard N. Pierson III
    • , Aaron J. Belli
    • , Eckhard Wolf
    • , Nikolai Klymiuk
    • , Carol Phelps
    • , Keith A. Reimann
    • , David Ayares
    •  & Keith A. Horvath
  • Reviews |

    The unique immunomodulatory properties of multipotent mesenchymal stromal cells (MSCs) make them a promising candidate for cell therapy in organ transplantation. Here, the authors review preclinical data that support the potential tolerance-inducing effects of MSCs in transplant models and the results of initial clinical studies in kidney transplantation.

    • Federica Casiraghi
    • , Norberto Perico
    • , Monica Cortinovis
    •  & Giuseppe Remuzzi
  • Reviews |

    The incidence of cancer in transplant recipients is indisputably higher than that of the age-matched general population, and the increased cancer development in transplant recipients who require immunosuppression to avoid graft rejection is well recognized. This Review discusses the advances with mTOR inhibitors that interfere with tumour development via immune and non-immune mechanisms, and the current and future perspectives on how best to normalize the unacceptably high rates of post-transplantation malignancies are highlighted.

    • Edward K. Geissler

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