Translation

Translation is the process by which a protein is synthesized by the ribosome, using a messenger RNA (mRNA) template.

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  • News and Views |

    A growing body of evidence suggests that cotranslational folding occurs from bacteria to mammalian cells, in particular for multi-domain proteins. In the assembly of yeast proteasomes, the initial interaction of Rpt1 and Rpt2 subunits has been found to take place on the translating ribosomes, coordinated by elongation pausing and involving the formation of Not1-containing compartments.

    • Xiao-Min Liu
    •  & Shu-Bing Qian
  • News and Views |

    Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.

    • Chih-Yung Lee
    •  & Geraldine Seydoux
    Nature Cell Biology 21, 116-117
  • News and Views |

    Recent advances in the ability to detect mRNA base modifications have led to a renewed appreciation for the diversity of the epitranscriptome and its ability to influence gene expression. Now, a study in Cell adds acetylated cytidine (ac4C) to the list, identifying it as a widespread mark in cellular mRNAs that influences both mRNA stability and translation.

    • Seung H. Choi
    •  & Kate D. Meyer