Transient receptor potential channels

Transient receptor potential channels (TRP channels) are ion channels that generally transport cations such as sodium, calcium and magnesium non-selectively across the plasma membrane. TRP channels are activated by various stimuli, including small molecules such as capsaicin, tetrahydrocannabinol and menthol, or by mechanical stresses and osmotic pressure.

Latest Research and Reviews

  • Reviews |

    Transient receptor potential (TRP) channels are a family of 28 nonselective cationic channels that are heterogeneously expressed in different regions and cell types of the heart. In this Review, the authors summarize the various physiological and pathological cardiac processes in which TRP channels are involved.

    • Thomas Hof
    • , Sébastien Chaigne
    • , Alice Récalde
    • , Laurent Sallé
    • , Fabien Brette
    •  & Romain Guinamard
  • Research | | open

    Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.

    • Lejla Zubcevic
    • , Mark A. Herzik Jr.
    • , Mengyu Wu
    • , William F. Borschel
    • , Marscha Hirschi
    • , Albert S. Song
    • , Gabriel C. Lander
    •  & Seok-Yong Lee
  • Reviews |

    In this Review, Haoxing Xu and colleagues summarize current knowledge of TRP channels and their roles in the response to environmental and cellular signals, focusing in particular on the least known class, the organellar TRPs.

    • Xiaoli Zhang
    • , Meiqin Hu
    • , Yexin Yang
    •  & Haoxing Xu
  • Research | | open

    Transient receptor potential mucolipin 1 (TRPML1) is a lysosomal channel which maintains the low pH and calcium levels for lysosomal function. Here authors use structural biology and electrophysiology to show how lipids bind and allosterically activate TRPML1.

    • Michael Fine
    • , Philip Schmiege
    •  & Xiaochun Li
  • Research | | open

    Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 and LPA-specific receptor antagonists ameliorate acute bronchoconstriction.

    • Nicholas G. Jendzjowsky
    • , Arijit Roy
    • , Nicole O. Barioni
    • , Margaret M. Kelly
    • , Francis H. Y. Green
    • , Christopher N. Wyatt
    • , Richard L. Pye
    • , Luana Tenorio-Lopes
    •  & Richard J. A. Wilson

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