Transforming growth factor beta

Definition

Transforming growth factor beta (TGFβ) is a cytokine that is secreted by various cell types, including macrophages, and functions in cell growth, cell differentiation, apoptosis and cellular homeostasis by binding to its receptor, the TGFβ type II receptor. Multiple signalling pathways lie downstream of the receptor, including the SMAD transcription factors and cell-cycle proteins.

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