Transcription factors

Transcription factors are proteins that bind to DNA to regulate gene expression via transcription: the process by which the genetic code generates mRNAs or small RNAs. Transcription factors operate by various methods, for example, by modulating the binding of RNA polymerase or by recruiting coactivator or corepressor proteins to the DNA.

Latest Research and Reviews

News and Comment

  • News and Views |

    Over-expression of a transcriptional factor, Alx3, has been shown to revitalize the regenerative capacity of adult progenitor cells to promote enhanced stromal vascularization and formation of parenchymal dental pulp tissue in vivo.

    • Sarah E. Millar
    Nature Materials 18, 530-531
  • Research Highlights |

    Failure of anticancer immune responses is often due to T cell dysfunction, but the molecular mechanisms underlying this are incompletely understood. Two papers in Nature now identify NR4A transcription factors as key drivers of T cell dysfunction.

    • Alexandra Flemming
  • News and Views |

    Transcription factors orchestrate stage-specific gene expression during development. Two such factors, TCF-1 and HEB, collaborate at the protein and genomic levels to regulate gene expression in developing thymocytes.

    • Christelle Harly
    •  & Thomas Ciucci
    Nature Immunology 19, 1283-1285
  • Research Highlights |

    Two new studies in Nature provide insight into the role of nucleosomes in gene regulation. One describes the genome-wide organization of nucleosomes and the other details how transcription factor binding to DNA is affected by the presence of nucleosomes.

    • Dorothy Clyde
  • Research Highlights |

    Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.

    • Ulrike Harjes