Totipotent stem cells

Totipotent stem cells are cells that have the capacity to self-renew by dividing and to develop into the three primary germ cell layers of the early embryo and into extra-embryonic tissues such as the placenta. A fertilised egg is a totipotent stem cell and as such can develop into any specialised cell found in the organism.

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Protocols | 07 January 2019

In vitro establishment of expanded-potential stem cells from mouse pre-implantation embryos or embryonic stem cells

Stem cells with blastomere-like features are derived from single eight-cell-stage blastomeres or whole eight-cell pre-implantation mouse embryos, or by conversion of mouse ES or induced pluripotent stem (iPS) cells reprogrammed from fibroblasts.
- Jian Yang
- , David J. Ryan
- , Guocheng Lan
- , Xiangang Zou
- & Pentao Liu
Nature Protocols 14, 350-378
Research | 11 October 2017

Establishment of mouse expanded potential stem cells

Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.
- Jian Yang
- , David J. Ryan
- , Wei Wang
- , Jason Cheuk-Ho Tsang
- , Guocheng Lan
- , Hideki Masaki
- , Xuefei Gao
- , Liliana Antunes
- , Yong Yu
- , Zhexin Zhu
- , Juexuan Wang
- , Aleksandra A. Kolodziejczyk
- , Lia S. Campos
- , Cui Wang
- , Fengtang Yang
- , Zhen Zhong
- , Beiyuan Fu
- , Melanie A. Eckersley-Maslin
- , Michael Woods
- , Yosuke Tanaka
- , Xi Chen
- , Adam C. Wilkinson
- , James Bussell
- , Jacqui White
- , Ramiro Ramirez-Solis
- , Wolf Reik
- , Berthold Göttgens
- , Sarah A. Teichmann
- , Patrick P. L. Tam
- , Hiromitsu Nakauchi
- , Xiangang Zou
- , Liming Lu
- & Pentao Liu
Nature 550, 393-397
Research | 13 July 2016 | open

Germline replacement by blastula cell transplantation in the fish medaka
- Mingyou Li
- , Ni Hong
- , Hongyan Xu
- , Jianxing Song
- & Yunhan Hong
Scientific Reports 6, 29658
Research | 13 June 2016 | open

Investigation of the cellular reprogramming phenomenon referred to as stimulus-triggered acquisition of pluripotency (STAP)
- Hitoshi Niwa
Scientific Reports 6, 28003
Research | 16 November 2015 | open

Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation
- Daishi Inoue
- , Hitoshi Aihara
- , Tatsuharu Sato
- , Hirofumi Mizusaki
- , Masamichi Doiguchi
- , Miki Higashi
- , Yuko Imamura
- , Mitsuhiro Yoneda
- , Takayuki Miyanishi
- , Satoshi Fujii
- , Akihiko Okuda
- , Takeya Nakagawa
- & Takashi Ito
Scientific Reports 5, 16567
Research | 28 October 2015 | open

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth
- Yu-ichi Tsukada
- , Tomohiko Akiyama
- & Keiichi I. Nakayama
Scientific Reports 5, 15876

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News and Comment

Research Highlights | 11 May 2018

The beginning of totipotency

Kikuë Tachibana discusses some of the key findings of the seminal works of Sir John Gurdon on nuclear reprogramming and how, by being examples of scientific rigour, they have inspired her own research.
- Kikuë Tachibana
Nature Reviews Molecular Cell Biology 19, 417
Research Highlights | 30 November 2017

Stem cells: Stem cells tip toward totipotency

Nature Methods 14, 1130
Correspondence | 24 September 2015

Failure to replicate the STAP cell phenomenon
- Alejandro De Los Angeles
- , Francesco Ferrari
- , Yuko Fujiwara
- , Ronald Mathieu
- , Soohyun Lee
- , Semin Lee
- , Ho-Chou Tu
- , Samantha Ross
- , Stephanie Chou
- , Minh Nguyen
- , Zhaoting Wu
- , Thorold W. Theunissen
- , Benjamin E. Powell
- , Sumeth Imsoonthornruksa
- , Jiekai Chen
- , Marti Borkent
- , Vladislav Krupalnik
- , Ernesto Lujan
- , Marius Wernig
- , Jacob H. Hanna
- , Konrad Hochedlinger
- , Duanqing Pei
- , Rudolf Jaenisch
- , Hongkui Deng
- , Stuart H. Orkin
- , Peter J. Park
- & George Q. Daley
Nature 525, E6-E9
Comments and Opinion | 05 April 2013

Correcting misperceptions about cryopreserved embryos and stem cell research
- Geoffrey P Lomax
- & Alan O Trounson
Nature Biotechnology 31, 288-290

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Totipotent stem cells

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