TOR signalling

TOR (target of rapamycin) signalling is a cell signalling pathway. TOR and its mammalian ortholog mTOR are serine-threonine kinases that sense growth factor, nutrient or oxygen status and promote appropriate changes in cell growth and proliferation, cell survival, and protein synthesis. TOR signalling has key roles in cancer and autophagy.

Latest Research and Reviews

  • Research |

    A set of 34 excised introns in Saccharomyces cerevisiae, characterized by having a short distance between the lariat branch point and the 3′ splice site, have a biological function within the TOR growth-signalling network.

    • Jeffrey T. Morgan
    • , Gerald R. Fink
    •  & David P. Bartel
    Nature 565, 606-611
  • Research | | open

    The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibrogenesis in in vitro and ex vivo models and that canonical PI3K/Akt signalling is dispensable.

    • Hannah V. Woodcock
    • , Jessica D. Eley
    • , Delphine Guillotin
    • , Manuela Platé
    • , Carmel B. Nanthakumar
    • , Matteo Martufi
    • , Simon Peace
    • , Gerard Joberty
    • , Daniel Poeckel
    • , Robert B. Good
    • , Adam R. Taylor
    • , Nico Zinn
    • , Matthew Redding
    • , Ellen J. Forty
    • , Robert E. Hynds
    • , Charles Swanton
    • , Morten Karsdal
    • , Toby M. Maher
    • , Giovanna Bergamini
    • , Richard P. Marshall
    • , Andy D. Blanchard
    • , Paul F. Mercer
    •  & Rachel C. Chambers
  • Reviews |

    This Review discusses the interdependencies of mTOR signalling and metabolism pathways in cancer and how metabolic reprogramming in response to changes in mTOR signalling and vice versa can sustain tumorigenicity. The authors highlight therapeutic opportunities when targeting metabolism and mTOR.

    • Dirk Mossmann
    • , Sujin Park
    •  & Michael N. Hall
    Nature Reviews Cancer 18, 744-757

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