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Tissues are ensembles of similar or compatible types of animal or plant cells that together carry out a specific function. In the human body there are four categories of tissues: epithelial, connective, nervous and muscle.
The application of engineered cardiac tissues is limited due to their immaturity and lack of functionality. Here, the authors develop an integrated culture platform featuring heart extracellular matrix cultured in a microfluidic chip to facilitate cardiac tissue development for versatile biomedical applications.
Implants made from patient-derived lyophilized lymph nodes loaded with chimeric antigen receptor T cells improve T cell delivery and inhibit tumour recurrence.
Implantation-associated infections often lead to infections. Here, the authors propose a piezo-based nanoreactor to achieve US-excited tandem catalysis, endowing the polyetherketoneketone bone scaffold with on-demand antibacterial and osteogenic capacities.
Automated extrusion-based bioprinting has been shown to enable human kidney organoid generation with improved throughput, quality control and scale, representing an important step towards macro-scale kidney tissue engineering.
As an intermediary between cells and scaffolding biomaterials, the extracellular matrix secreted by the cells offers challenges and opportunities for the design and fabrication of engineered tissues.
Epithelial layers under compression avoid buckling by active contraction, but only up to a well-defined threshold at 35% strain, beyond which buckling occurs.
