Testicular cancer

Definition

Testicular cancer is a cancer that starts in the testis. The majority (95%) of testicular cancers are germ cell tumours. Treatment for testicular cancer is highly effective, with 5-year overall survival rates approaching 100% for localized disease.

Latest Research and Reviews

  • Research |

    Katherine Nathanson, Peter Kanetsky and colleagues present a meta-analysis of five genome-wide association studies of testicular germ cell tumor (TGCT). They identify eight new susceptibility loci and new independent signals at two previously reported loci, providing further clues to the etiology of TGCT.

    • Zhaoming Wang
    • , Katherine A McGlynn
    • , Ewa Rajpert-De Meyts
    • , D Timothy Bishop
    • , Charles C Chung
    • , Marlene D Dalgaard
    • , Mark H Greene
    • , Ramneek Gupta
    • , Tom Grotmol
    • , Trine B Haugen
    • , Robert Karlsson
    • , Kevin Litchfield
    • , Nandita Mitra
    • , Kasper Nielsen
    • , Louise C Pyle
    • , Stephen M Schwartz
    • , Vésteinn Thorsson
    • , Saran Vardhanabhuti
    • , Fredrik Wiklund
    • , Clare Turnbull
    • , Stephen J Chanock
    • , Peter A Kanetsky
    • , Katherine L Nathanson
    • , the Testicular Cancer Consortium
    • , Katherine A McGlynn
    • , Ewa Rajpert-De Meyts
    • , D Timothy Bishop
    • , Mark H Greene
    • , Ramneek Gupta
    • , Tom Grotmol
    • , Trine B Haugen
    • , Stephen M Schwartz
    • , Fredrik Wiklund
    • , Clare Turnbull
    • , Stephen J Chanock
    • , Peter A Kanetsky
    • , Katherine L Nathanson
    • , Alberto Ferlin
    • , Jourik A Gietema
    • , Victoria Cortessis
    • , Russ Hauser
    • , Michelle Hildebrandt
    • , Lambertus A Kiemeney
    • , Christian Kubisch
    • , Davor Lessel
    • , Thorunn Rafnar
    • , Lorenzo Richiardi
    • , Rolf Skotheim
    •  & Tongzhang Zheng
    Nature Genetics 49, 1141–1147
  • Research | | open

    Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

    • Jun Fang
    • , Jinping Jia
    • , Matthew Makowski
    • , Mai Xu
    • , Zhaoming Wang
    • , Tongwu Zhang
    • , Jason W. Hoskins
    • , Jiyeon Choi
    • , Younghun Han
    • , Mingfeng Zhang
    • , Janelle Thomas
    • , Michael Kovacs
    • , Irene Collins
    • , Marta Dzyadyk
    • , Abbey Thompson
    • , Maura O’Neill
    • , Sudipto Das
    • , Qi Lan
    • , Roelof Koster
    • , PanScan Consortium
    • , Federico Canzian
    • , Charles Kooperberg
    • , Zhaoming Wang
    • , Alan A Arslan
    • , Paige M Bracci
    • , Julie Buring
    • , Eric J Duell
    • , Steven Gallinger
    • , Eric J Jacobs
    • , Aruna Kamineni
    • , Stephen Van Den Eeden
    • , Alison P Klein
    • , Laurence N Kolonel
    • , Donghui Li
    • , Sara H Olson
    • , Harvey A Risch
    • , Howard D Sesso
    • , Kala Visvanathan
    • , Wei Zheng
    • , Demetrius Albanes
    • , Melissa A Austin
    • , Marie-Christine Boutron-Ruault
    • , H Bas Bueno-de-Mesquita
    • , Michelle Cotterchio
    • , J Michael Gaziano
    • , Edward L Giovannucci
    • , Michael Goggins
    • , Myron Gross
    • , Manal Hassan
    • , Kathy J Helzlsouer
    • , Elizabeth A Holly
    • , David J Hunter
    • , Mazda Jenab
    • , Rudolf Kaaks
    • , Timothy J Key
    • , Kay-Tee Khaw
    • , Vittorio Krogh
    • , Robert C Kurtz
    • , Andrea LaCroix
    • , Loic Le Marchand
    • , Satu Mannisto
    • , Alpa V Patel
    • , Petra H M Peeters
    • , Elio Riboli
    • , Xiao-Ou Shu
    • , Malin Sund
    • , Mark Thornquist
    • , Anne Tjønneland
    • , Geoffrey S Tobias
    • , Dimitrios Trichopoulos
    • , Jean Wactawski-Wende
    • , Herbert Yu
    • , Kai Yu
    • , Anne Zeleniuch-Jacquotte
    • , Robert Hoover
    • , Patricia Hartge
    • , Charles Fuchs
    • , Stephen J Chanock
    • , TRICL Consortium
    • , Victoria Stevens
    • , Demetrios Albanes
    • , Neil E Caporaso
    • , Paul Brennan
    • , James McKay
    • , Xifeng Wu
    • , Rayjean J Hung
    • , John R McLaughlin
    • , Heike Bickeboller
    • , Angela Risch
    • , Erich Wichmann
    • , Richard Houlston
    • , GenoMEL Consortium
    • , Graham Mann
    • , John Hopper
    • , Joanne Aitken
    • , Bruce Armstrong
    • , Graham Giles
    • , Elizabeth Holland
    • , Richard Kefford
    • , Anne Cust
    • , Mark Jenkins
    • , Helen Schmid
    • , Susana Puig
    • , Paula Aguilera
    • , Celia Badenas
    • , Alicia Barreiro
    • , Cristina Carrera
    • , Daniel Gabriel
    • , Pol Gimenez Xavier
    • , Pablo Iglesias-Garcia
    • , Josep Malvehy
    • , Montse Mila
    • , Ramon Pigem
    • , Miriam Potrony
    • , Joan-AntonPuig Batille
    • , Gemma Tell-Marti
    • , Nick Hayward
    • , Nicholas Martin
    • , Grant Montgomery
    • , David Duffy
    • , David Whiteman
    • , Stuart Mac Gregor
    • , Donato Calista
    • , Giorgi Landi
    • , Paola Minghetti
    • , Fabio Arcangeli
    • , Pier Alberto Bertazzi
    • , Paola Ghiorzo
    • , Giovanna Bianchi Scarra
    • , Lorenze Pastorino
    • , William Bruno
    • , Virginia Andreotti
    • , Paola Queirolo
    • , Francesco Spagnolo
    • , Rona Mackie
    • , Julie Lang
    • , Nelleke Gruis
    • , Frans A van Nieuwpoort
    • , Coby Out
    • , Wilma Bergman
    • , Nicole Kukutsch
    • , Jan Nico Bouwes Bavinck
    • , Bert Bakker
    • , Nienke van der Stoep
    • , Jeanet ter Huurne
    • , Han van der Rhee
    • , Marcel Bekkenk
    • , Dyon Snels
    • , Marinus van Praag
    • , Lieve Brochez
    • , Rianne Gerritsen
    • , Marianne Crijns
    • , Hans Vasen
    • , Bart Janssen
    • , Christian Ingvar
    • , Hakan Olsson
    • , Goran Jonsson
    • , Ake Borg
    • , Katja Harbst
    • , Kari Nielsen
    • , Anita Schmidt Zander
    • , Anders Molvern
    • , Per Helsing
    • , Per Arne Andresen
    • , Helge Rootwelt
    • , Lars A Akslen
    • , Brigitte Bressac-de Paillerets
    • , Florence Demenais
    • , Marie-Francoise Avril
    • , Valerie Chaudru
    • , Patricia Jeannin
    • , Fabienne Lesueur
    • , Eve Maubec
    • , Hamida Mohamdi
    • , Myriam Bossard
    • , Amaury Vaysse
    • , Francoise Boitier
    • , Oliver Caron
    • , Frederic Caux
    • , Stephane Dalle
    • , Oliviier Dereure
    • , Dominique Leroux
    • , Ludovic Martin
    • , Christine Mateus
    • , Caroline Robert
    • , Dominique Stoppa-Lyonnet
    • , Luc Thomas
    • , Eva Wierzbicka
    • , David Elder
    • , Michael Ming
    • , Nandita Mitra
    • , Tadeusz Debniak
    • , Jan Lubinski
    • , Marko Hocevar
    • , Srdjan Novakovic
    • , Barbara Peric
    • , Petra Skerl
    • , Johan Hansson
    • , Veronica Hoiom
    • , Eitan Freidman
    • , Esther Azizi
    • , Orna Baron-Epel
    • , Alon Scope
    • , Felix Pavlotsky
    • , Irit Cohen-Manheim
    • , Yael Laitman
    • , Mark Harland
    • , Juliette Randerson-Moor
    • , Jon Laye
    • , John Davies
    • , Jeremie Nsengimana
    • , Sally O'Shea
    • , May Chan
    • , Jo Gascoyne
    • , Margaret A Tucker
    • , Alisa M Goldstein
    • , Xiaohong R Yang
    • , Rachael S. Stolzenberg-Solomon
    • , Peter Kraft
    • , Brian M. Wolpin
    • , Pascal W. T. C. Jansen
    • , Sara Olson
    • , Katherine A. McGlynn
    • , Peter A. Kanetsky
    • , Nilanjan Chatterjee
    • , Jennifer H. Barrett
    • , Alison M. Dunning
    • , John C. Taylor
    • , Julia A. Newton-Bishop
    • , D. Timothy Bishop
    • , Thorkell Andresson
    • , Gloria M. Petersen
    • , Christopher I. Amos
    • , Mark M. Iles
    • , Katherine L. Nathanson
    • , Maria Teresa Landi
    • , Michiel Vermeulen
    • , Kevin M. Brown
    •  & Laufey T. Amundadottir
  • Reviews |

    A need for improved serum diagnostic tests for testicular germ cell tumours (GCTs) exists owing to the unsatisfactory performance of currently used markers. In this Review, Murray and colleagues discuss the current serum diagnostic tests for testicular GCTs, including α-fetoprotein, human chorionic gonadotrophin and lactate dehydrogenase, and the future use of novel universal biomarkers such as microRNAs.

    • Matthew J. Murray
    • , Robert A. Huddart
    •  & Nicholas Coleman
  • Reviews |

    Care must be taken to limit the long-term risks of treatment of stage I testicular germ cell tumours (TGCT) as long-term survival is 99%. The management of this disease remains controversial as the options are to overtreat to prevent relapse, or to observe and treat only patients who experience disease relapse. In this Review, Chovanec and colleagues discuss the options for the management of clinical stage I TGCT.

    • Michal Chovanec
    • , Nasser Hanna
    • , K. Clint Cary
    • , Lawrence Einhorn
    •  & Costantine Albany

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