T-helper 2 cells

Definition

T-helper 2 cells are a specialized population of T cells. They are important for immune responses against pathogens that do not directly infect cells, such as helminth parasites. They also promote tissue repair, but contribute to allergic disorders and diseases such as asthma.

Latest Research and Reviews

  • Research | | open

    T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Treg cell IL-4 production and metabolic alteration to preserve Treg lineage and function.

    • Awo Akosua Kesewa Layman
    • , Guoping Deng
    • , Claire E. O’Leary
    • , Samuel Tadros
    • , Rajan M. Thomas
    • , Joseph M. Dybas
    • , Emily K. Moser
    • , Andrew D. Wells
    • , Nicolai M. Doliba
    •  & Paula M. Oliver
  • Research |

    Type 2 responses can be elicited by ILC2s and TH2 cells. Locksley and colleagues show that the epithelium-derived cytokines IL-25, IL-33 and TSLP are required for full effector activation of poised ILC2 and primed TH2 cell populations.

    • Steven J Van Dyken
    • , Jesse C Nussbaum
    • , Jinwoo Lee
    • , Ari B Molofsky
    • , Hong-Erh Liang
    • , Joshua L Pollack
    • , Rachel E Gate
    • , Genevieve E Haliburton
    • , Chun J Ye
    • , Alexander Marson
    • , David J Erle
    •  & Richard M Locksley
    Nature Immunology 17, 1381–1387
  • Reviews |

    The cytokine interleukin-33 was first identified as an inducer of type 2 immune responses. It has now been shown to have pleiotropic activities on multiple immune cell types and is involved in numerous infectious and inflammatory diseases, as described in this Review.

    • Foo Yew Liew
    • , Jean-Philippe Girard
    •  & Heth Roderick Turnquist
  • Research | | open

    Type 2 immune responses are viewed as opposites of Type 1 and 17 responses. Here the authors show that activation of Type 2 immunity by helminth infection counteracts the development of inflammatory arthritis, a type 17-mediated pathology, via IL-4/IL-13- STAT6 signalling and eosinophil activation.

    • Zhu Chen
    • , Darja Andreev
    • , Katharina Oeser
    • , Branislav Krljanac
    • , Axel Hueber
    • , Arnd Kleyer
    • , David Voehringer
    • , Georg Schett
    •  & Aline Bozec
  • Research | | open

    Although IFNγ is a Th1 signature cytokine and is repressed in Th2 cells, it is reactivated in a subset of memory Th2 cells. Here the authors show that Hdac2 is released from Gata3 by Akt-mediated phosphorylation, leading to transcriptional derepression of Tbx21 and IFNγ in these cells.

    • Hiroyuki Hosokawa
    • , Tomoaki Tanaka
    • , Yusuke Endo
    • , Miki Kato
    • , Kenta Shinoda
    • , Akane Suzuki
    • , Shinichiro Motohashi
    • , Masaki Matsumoto
    • , Keiichi I. Nakayama
    •  & Toshinori Nakayama

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