T-helper 17 cells

Definition

T-helper 17 cells are a specialized population of T cells that produce a pro-inflammatory molecule known as interleukin-17. They are important for immunity to certain bacterial and fungal infections. They also contribute to certain inflammatory conditions, such as inflammatory bowel disease.

Latest Research and Reviews

  • Research | | open

    Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells

    • Andrea Romagnani
    • , Valentina Vettore
    • , Tanja Rezzonico-Jost
    • , Sarah Hampe
    • , Elsa Rottoli
    • , Wiebke Nadolni
    • , Michela Perotti
    • , Melanie A. Meier
    • , Constanze Hermanns
    • , Sheila Geiger
    • , Gunther Wennemuth
    • , Camilla Recordati
    • , Masayuki Matsushita
    • , Susanne Muehlich
    • , Michele Proietti
    • , Vladimir Chubanov
    • , Thomas Gudermann
    • , Fabio Grassi
    •  & Susanna Zierler
  • Research | | open

    CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “pathogenic” mouse TH 17 but distinct from “non-pathogenic” mouse TH 17.

    • Dan Hu
    • , Samuele Notarbartolo
    • , Tom Croonenborghs
    • , Bonny Patel
    • , Ron Cialic
    • , Tun-Hsiang Yang
    • , Dominik Aschenbrenner
    • , Karin M. Andersson
    • , Marco Gattorno
    • , Minh Pham
    • , Pia Kivisakk
    • , Isabelle V. Pierre
    • , Youjin Lee
    • , Karun Kiani
    • , Maria Bokarewa
    • , Emily Tjon
    • , Nathalie Pochet
    • , Federica Sallusto
    • , Vijay K. Kuchroo
    •  & Howard L. Weiner
  • Research | | open

    Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a unique transcriptional profile including enhanced GPR65 expression.

    • M. H. Al-Mossawi
    • , L. Chen
    • , H. Fang
    • , A. Ridley
    • , J. de Wit
    • , N. Yager
    • , A. Hammitzsch
    • , I. Pulyakhina
    • , B. P. Fairfax
    • , D. Simone
    • , Yao Yi
    • , S. Bandyopadhyay
    • , K. Doig
    • , R Gundle
    • , B. Kendrick
    • , F. Powrie
    • , J. C. Knight
    •  & P. Bowness
  • Research |

    TGFβ signalling regulates T helper 17 (TH17) cell differentiation by reversing SKI–SMAD4-mediated suppression of RORγt, revealing a potential therapeutic target for treating TH17-related diseases.

    • Song Zhang
    • , Motoki Takaku
    • , Liyun Zou
    • , Ai-di Gu
    • , Wei-chun Chou
    • , Ge Zhang
    • , Bing Wu
    • , Qing Kong
    • , Seddon Y. Thomas
    • , Jonathan S. Serody
    • , Xian Chen
    • , Xiaojiang Xu
    • , Paul A. Wade
    • , Donald N. Cook
    • , Jenny P. Y. Ting
    •  & Yisong Y. Wan
    Nature 551, 105–109
  • Research | | open

    The transcription factor Foxo1 can control regulatory T cell and Th1 function. Here the authors show that Foxo1 is also critical for IL-9 production by Th9 cells and other IL-9-producing cells.

    • Sakshi Malik
    • , Srikanth Sadhu
    • , Srikanth Elesela
    • , Ramendra Pati Pandey
    • , Amanpreet Singh Chawla
    • , Deepak Sharma
    • , Lipsa Panda
    • , Deepak Rathore
    • , Balram Ghosh
    • , Vineet Ahuja
    •  & Amit Awasthi
  • Research |

    Targeting the transcription factor RORγt in autoimmunity could disrupt thymocyte development and lead to thymic lymphoma. Sun and colleagues identify a two-amino-acid substitution in RORγt that ‘preferentially’ disrupts TH17 differentiation, not thymocyte development.

    • Zhiheng He
    • , Jian Ma
    • , Ruiqing Wang
    • , Jing Zhang
    • , Zhaofeng Huang
    • , Fei Wang
    • , Subha Sen
    • , Ellen V Rothenberg
    •  & Zuoming Sun
    Nature Immunology 18, 1128–1138

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