T-helper 17 cells

T-helper 17 cells are a specialized population of T cells that produce a pro-inflammatory molecule known as interleukin-17. They are important for immunity to certain bacterial and fungal infections. They also contribute to certain inflammatory conditions, such as inflammatory bowel disease.

Latest Research and Reviews

  • Research | | open

    Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.

    • Maik Luu
    • , Sabine Pautz
    • , Vanessa Kohl
    • , Rajeev Singh
    • , Rossana Romero
    • , Sébastien Lucas
    • , Jörg Hofmann
    • , Hartmann Raifer
    • , Niyati Vachharajani
    • , Lucia Campos Carrascosa
    • , Boris Lamp
    • , Andrea Nist
    • , Thorsten Stiewe
    • , Yoav Shaul
    • , Till Adhikary
    • , Mario M. Zaiss
    • , Matthias Lauth
    • , Ulrich Steinhoff
    •  & Alexander Visekruna
  • Research | | open

    Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation of pathogenic Th17 cells and susceptibility to a mouse model of multiple sclerosis.

    • Jonathan J. Cho
    • , Zhiwei Xu
    • , Upasana Parthasarathy
    • , Theodore T. Drashansky
    • , Eric Y. Helm
    • , Ashley N. Zuniga
    • , Kyle J. Lorentsen
    • , Samira Mansouri
    • , Joshua Y. Cho
    • , Mariola J. Edelmann
    • , Duc M. Duong
    • , Torben Gehring
    • , Thomas Seeholzer
    • , Daniel Krappmann
    • , Mohammad N. Uddin
    • , Danielle Califano
    • , Rejean L. Wang
    • , Lei Jin
    • , Hongmin Li
    • , Dongwen Lv
    • , Daohong Zhou
    • , Liang Zhou
    •  & Dorina Avram
  • Research | | open

    A chromatin remodelling factor Satb1 is essential for T cell lineage development in the thymus. Here the authors show that while Satb1 is dispensable for the differentiation of Th17 cells and their response to gut commensals, it plays a critical role in pathogenic Th17 effector function in EAE by directly activating Bhlhe40 and modulating PD-1.

    • Keiko Yasuda
    • , Yohko Kitagawa
    • , Ryoji Kawakami
    • , Yoshitaka Isaka
    • , Hitomi Watanabe
    • , Gen Kondoh
    • , Terumi Kohwi-Shigematsu
    • , Shimon Sakaguchi
    •  & Keiji Hirota
  • Research |

    Phenotypically, transcriptionally and metabolically diverse subsets of TH17 cells develop in a chronic autoimmune disease: one subset has inferred stemness features and low anabolic metabolism, while a reciprocal subset has higher metabolic activity that supports transdifferentiation into TH1 cells.

    • Peer W. F. Karmaus
    • , Xiang Chen
    • , Seon Ah Lim
    • , Andrés A. Herrada
    • , Thanh-Long M. Nguyen
    • , Beisi Xu
    • , Yogesh Dhungana
    • , Sherri Rankin
    • , Wenan Chen
    • , Celeste Rosencrance
    • , Kai Yang
    • , Yiping Fan
    • , Yong Cheng
    • , John Easton
    • , Geoffrey Neale
    • , Peter Vogel
    •  & Hongbo Chi
    Nature 565, 101-105
  • Research | | open

    The transcription factor RORγt is essential for the differentiation of TH17 cells, thymocyte development and lymphoid organogenesis. Here the authors show that the function of RORγt is regulated by PIAS4-mediated sumoylation that stabilize the interaction with SRC1 and KAT2A, to enhance the transcriptional activity of RORγt.

    • Zhiheng He
    • , Jing Zhang
    • , Zhaofeng Huang
    • , Qian Du
    • , Ning Li
    • , Qiang Zhang
    • , Yuan Chen
    •  & Zuoming Sun
  • Research | | open

    Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the transcription of Foxp3 to alter Treg lineage stability.

    • Sung-Min Hwang
    • , Garima Sharma
    • , Ravi Verma
    • , Seohyun Byun
    • , Dipayan Rudra
    •  & Sin-Hyeog Im

News and Comment