T cells

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to sense and respond to diverse types of infection.

Featured

Latest Research and Reviews

  • Research |

    Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs

    • Felipe A. Vieira Braga
    • , Gozde Kar
    • , Marijn Berg
    • , Orestes A. Carpaij
    • , Krzysztof Polanski
    • , Lukas M. Simon
    • , Sharon Brouwer
    • , Tomás Gomes
    • , Laura Hesse
    • , Jian Jiang
    • , Eirini S. Fasouli
    • , Mirjana Efremova
    • , Roser Vento-Tormo
    • , Carlos Talavera-López
    • , Marnix R. Jonker
    • , Karen Affleck
    • , Subarna Palit
    • , Paulina M. Strzelecka
    • , Helen V. Firth
    • , Krishnaa T. Mahbubani
    • , Ana Cvejic
    • , Kerstin B. Meyer
    • , Kourosh Saeb-Parsy
    • , Marjan Luinge
    • , Corry-Anke Brandsma
    • , Wim Timens
    • , Ilias Angelidis
    • , Maximilian Strunz
    • , Gerard H. Koppelman
    • , Antoon J. van Oosterhout
    • , Herbert B. Schiller
    • , Fabian J. Theis
    • , Maarten van den Berge
    • , Martijn C. Nawijn
    •  & Sarah A. Teichmann
  • Research |

    Treg cells are essential for self-tolerance. Huseby and colleagues identify multiple de facto Treg cell self-peptides and show that Treg cells are exported from the thymus within a defined postnatal developmental window that is controlled by their increased negative selection.

    • Brian D. Stadinski
    • , Sydney J. Blevins
    • , Nicholas A. Spidale
    • , Brian R. Duke
    • , Priya G. Huseby
    • , Lawrence J. Stern
    •  & Eric S. Huseby
  • Research |

    • Andrew C. Scott
    • , Friederike Dündar
    • , Paul Zumbo
    • , Smita S. Chandran
    • , Christopher A. Klebanoff
    • , Mojdeh Shakiba
    • , Prerak Trivedi
    • , Laura Menocal
    • , Heather Appleby
    • , Steven J. Camara
    • , Dmitriy Zamarin
    • , Tyler Walther
    • , Alexandra C. Snyder
    • , Matthew R. Femia
    • , Elizabeth A. Comen
    • , Hannah Y. Wen
    • , Matthew D. Hellmann
    • , Niroshana Anandasabapathy
    • , Yong Liu
    • , Nasser K. Altorki
    • , Peter Lauer
    • , Olivier Levy
    • , Michael Glickman
    • , Jonathan Kaye
    • , Doron Betel
    • , Mary Philip
    •  & Andrea Schietinger
    Nature, 1-8
  • Research |

    Long-lived, self-renewing ‘progenitor-like’ CD8+ T cells can arise during chronic viral infection or in cancer. Wu and colleagues identify the transcription factor TOX as essential to endow ‘stemness’ and long-term persistence in the face of chronic infection.

    • Chen Yao
    • , Hong-Wei Sun
    • , Neal E. Lacey
    • , Yun Ji
    • , E. Ashley Moseman
    • , Han-Yu Shih
    • , Elisabeth F. Heuston
    • , Martha Kirby
    • , Stacie Anderson
    • , Jun Cheng
    • , Omar Khan
    • , Robin Handon
    • , Julie Reilley
    • , Jessica Fioravanti
    • , Jinhui Hu
    • , Selamawit Gossa
    • , E. John Wherry
    • , Luca Gattinoni
    • , Dorian B. McGavern
    • , John J. O’Shea
    • , Pamela L. Schwartzberg
    •  & Tuoqi Wu
    Nature Immunology 20, 890-901
  • Research |

    • Omar Khan
    • , Josephine R. Giles
    • , Sierra McDonald
    • , Sasikanth Manne
    • , Shin Foong Ngiow
    • , Kunal P. Patel
    • , Michael T. Werner
    • , Alexander C. Huang
    • , Katherine A. Alexander
    • , Jennifer E. Wu
    • , John Attanasio
    • , Patrick Yan
    • , Sangeeth M. George
    • , Bertram Bengsch
    • , Ryan P. Staupe
    • , Greg Donahue
    • , Wei Xu
    • , Ravi K. Amaravadi
    • , Xiaowei Xu
    • , Giorgos C. Karakousis
    • , Tara C. Mitchell
    • , Lynn M. Schuchter
    • , Jonathan Kaye
    • , Shelley L. Berger
    •  & E. John Wherry
    Nature, 1-13

News and Comment