T cells

Definition

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to sense and respond to diverse types of infection.

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Latest Research and Reviews

  • Research | | open

    T cells need to undergo rapid proliferation in response to antigenic stimulation. Here the authors show that the Ets family transcription factor GABP is required for T-cell homeostasis and response to infection by inducing Mcm3 and Mcm5 expression and enabling S-phase entry.

    • Chong T. Luo
    • , Hatice U. Osmanbeyoglu
    • , Mytrang H. Do
    • , Michael R. Bivona
    • , Ahmed Toure
    • , Davina Kang
    • , Yuchen Xie
    • , Christina S. Leslie
    •  & Ming O. Li
  • Research | | open

    Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVHD while GC is dispensable.

    • Ruishu Deng
    • , Christian Hurtz
    • , Qingxiao Song
    • , Chanyu Yue
    • , Gang Xiao
    • , Hua Yu
    • , Xiwei Wu
    • , Markus Muschen
    • , Stephen Forman
    • , Paul J. Martin
    •  & Defu Zeng
  • Research | | open

    Thymocytes are screened by two processes, termed positive and negative selections, which are permissive only for immature thymocytes with intermediate avidity to the selecting ligands. Here the authors show that the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival.

    • Jianrong Wang
    • , Nanhai He
    • , Na Zhang
    • , Dexian Quan
    • , Shuo Zhang
    • , Caroline Zhang
    • , Ruth T. Yu
    • , Annette R. Atkins
    • , Ruihong Zhu
    • , Chunhui Yang
    • , Ying Cui
    • , Christopher Liddle
    • , Michael Downes
    • , Hui Xiao
    • , Ye Zheng
    • , Johan Auwerx
    • , Ronald M. Evans
    •  & Qibin Leng
  • Research | | open

    Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival outcomes post CTLA4-Ig treatment.

    • Mayuko Uehara
    • , Martina M. McGrath
    • , Shunsuke Ohori
    • , Zhabiz Solhjou
    • , Naima Banouni
    • , Sujit Routray
    • , Catherine Evans
    • , Jonathan P. DiNitto
    • , Abdallah Elkhal
    • , Laurence A. Turka
    • , Terry B. Strom
    • , Stefan G. Tullius
    • , David G. Winkler
    • , Jamil Azzi
    •  & Reza Abdi
  • Reviews |

    In this Review, the authors detail the complex expression patterns and regulation of programmed cell death protein 1 (PD1) and its ligands. The authors focus on the importance of understanding these pathways in order to optimize the efficiency and safety of immune checkpoint blockade in patients.

    • Arlene H. Sharpe
    •  & Kristen E. Pauken

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