Nature

T-cell lymphoma articles from across Nature Portfolio

T-cell lymphomas are a type of non-Hodgkin lymphoma that involve the malignant transformation of T cells. Four major types have been characterized: extranodal T-cell lymphoma, cutaneous T-cell lymphomas (Sézary syndrome and Mycosis fungoides), anaplastic large cell lymphoma and angioimmunoblastic T-cell lymphoma.

Latest Research and Reviews

Long term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome
- S. L. Morris
- B. R. Thomas
- E. Kanfer
ResearchOpen Access12 Mar 2024 Bone Marrow Transplantation
P: 1-6
Dual T-cell constant β chain (TRBC)1 and TRBC2 staining for the identification of T-cell neoplasms by flow cytometry
- Pedro Horna
- Matthew J. Weybright
- Horatiu Olteanu
ResearchOpen Access29 Feb 2024 Blood Cancer Journal
Volume: 14, P: 34
Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset
- Mark P. Little
- Jim Z. Mai
- Michael G. Kimlin
ResearchOpen Access29 Feb 2024 British Journal of Cancer
P: 1-12
Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies

The T cell receptor β-chain is expressed in two isoforms, TRBC1 and TRBC2, with clonally expanded mature T cell lymphomas expressing one of them exclusively, while healthy T cells randomly express either TRBC1 or TRBC2. Here authors show structure-based design of a TRBC2-specific antibody, and depletion of malignant T cells carrying TRBC1 or TRBC2 with CAR-T cells against the cognate receptor chain in murine models.
- Mathieu Ferrari
- Matteo Righi
- Martin Pule
ResearchOpen Access21 Feb 2024 Nature Communications
Volume: 15, P: 1583
Genomic features reveal potential benefit of adding anti-PD-1 immunotherapy to treat non-upper aerodigestive tract natural killer/T-cell lymphoma
- Zegeng Chen
- He Huang
- Tongyu Lin
Research20 Feb 2024 Leukemia
Volume: 38, P: 829-839
Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution
- Sakurako Suma
- Yasuhito Suehara
- Mamiko Sakata-Yanagimoto
ResearchOpen Access27 Nov 2023 Leukemia
Volume: 38, P: 340-350

All Research & Reviews

News and Comment

A comparison of long-term outcomes by donor type in the era of post-transplantation cyclophosphamide for aggressive adult T-cell leukemia/lymphoma
- Asao Hirose
- Hideo Koh
- Hirohisa Nakamae
Correspondence14 Feb 2024 Bone Marrow Transplantation
P: 1-4
PD-1 takes control
- Stephanie Houston
Research Highlights16 Oct 2023 Nature Immunology
Volume: 24, P: 1781
Incidence and course of Epstein-Barr virus viremia after allogeneic hematopoietic stem cell transplant for adult-onset systemic chronic active Epstein-Barr virus disease
- Preeti Prerna M. Vaswani
- Masahiro Onozawa
- Takanori Teshima
Correspondence05 Sept 2023 Bone Marrow Transplantation
Volume: 58, P: 1397-1399
HSCT prolongs remission of high-risk CTCLs
- David Killock
Research Highlights05 May 2023 Nature Reviews Clinical Oncology
Volume: 20, P: 426
The clinical benefit of acute GVHD depends on the age at transplantation in patients with adult T-cell leukemia–lymphoma on behalf of the ATL Working Group of the Japan Society for Transplantation and Cellular Therapy
- Shigeo Fuji
- Yoshitaka Inoue
- Makoto Yoshimitsu
Correspondence25 Mar 2023 Bone Marrow Transplantation
Volume: 58, P: 729-731
Long-term outcomes for allogeneic bone marrow transplantation in Sezary syndrome and mycosis fungoides
- Jessica Elliott
- Shalini Ahlawat
- Amit Khot
Correspondence26 Aug 2022 Bone Marrow Transplantation
Volume: 57, P: 1724-1726

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