Synthetic biology

Synthetic biology is the design and construction of new biological parts, devices, and systems, and the re-design of existing, natural biological systems for useful purposes.

Latest Research and Reviews

  • Research |

    Nucleic acid nanotechnology offers a promising route towards the design and synthesis of reconfigurable biomolecular materials. Now, the combination of dynamic and structural DNA nanotechnology has enabled the dynamic control of the assembly and disassembly of DNA nanotubes. The process involves minimal synthetic gene systems, including an autonomous molecular oscillator.

    • Leopold N. Green
    • , Hari K. K. Subramanian
    • , Vahid Mardanlou
    • , Jongmin Kim
    • , Rizal F. Hariadi
    •  & Elisa Franco
  • Research |

    The highly charged phosphodiester chemistry of the natural nucleic acids DNA and RNA has been widely considered to be indispensable for their function as informational molecules. Now, synthetic genetic polymers with an uncharged alkyl phosphonate backbone chemistry have been shown to enable genetic information transfer and evolution.

    • Sebastian Arangundy-Franklin
    • , Alexander I. Taylor
    • , Benjamin T. Porebski
    • , Vito Genna
    • , Sew Peak-Chew
    • , Alexandra Vaisman
    • , Roger Woodgate
    • , Modesto Orozco
    •  & Philipp Holliger
  • Research | | open

    The understanding of liquid-liquid phase separation is crucial to cell biology and benefits from cell-mimicking in vitro assays. Here, the authors develop a microfluidic platform to study coacervate formation inside liposomes and show the potential of these hybrid systems to create synthetic cells.

    • Siddharth Deshpande
    • , Frank Brandenburg
    • , Anson Lau
    • , Mart G. F. Last
    • , Willem Kasper Spoelstra
    • , Louis Reese
    • , Sreekar Wunnava
    • , Marileen Dogterom
    •  & Cees Dekker
  • Research | | open

    The range of chemicals detectable by cell-free systems is still limited. Here the authors combine metabolic cascades with transcription factor networks to detect small molecules in complex environments.

    • Peter L. Voyvodic
    • , Amir Pandi
    • , Mathilde Koch
    • , Ismael Conejero
    • , Emmanuel Valjent
    • , Philippe Courtet
    • , Eric Renard
    • , Jean-Loup Faulon
    •  & Jerome Bonnet
  • Research | | open

    Gene-drives use CRISPR-Cas9 to be transmitted in a super-Mendelian fashion. Here the authors develop an allelic-drive for selective inheritance of a desired allele.

    • Annabel Guichard
    • , Tisha Haque
    • , Marketta Bobik
    • , Xiang-Ru S. Xu
    • , Carissa Klanseck
    • , Raja Babu Singh Kushwah
    • , Mateus Berni
    • , Bhagyashree Kaduskar
    • , Valentino M. Gantz
    •  & Ethan Bier

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