Synaptic plasticity

Synaptic plasticity is the biological process by which specific patterns of synaptic activity result in changes in synaptic strength and is thought to contribute to learning and memory. Both pre-synaptic and post-synaptic mechanisms can contribute to the expression of synaptic plasticity.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    The encoding of salient events as memory traces involves the selective activation of specific neurons in the hippocampus and the inhibition of others, a process shown here to be regulated by GABAergic input from the nucleus incertus in the brainstem.

    • Sian Lewis
  • Research Highlights |

    Repetitive sensory input induces long-term potentiation of pyramidal cell synapses in mouse somatosensory cortex by activation of higher-order thalamic projections and disinhibition of local interneurons.

    • Sian Lewis
  • Research Highlights |

    Mice receiving autoantibodies against the GluA2 AMPA receptor subunit from individuals with autoimmune encephalitis exhibit changes in AMPA receptor subunit composition and impaired synaptic plasticity and memory.

    • Darran Yates