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Surface plasmon resonance (SPR) spectroscopy is a technique to detect biomolecular binding interactions. In SPR, one molecular partner is immobilized on a metallic film. Light excites surface plasmons in the metal; when the binding partner binds to the immobilized molecule, this causes a detectable change in the surface plasmon signal.
The authors developed a pristine hyperspectral SPR microscopy that enables monochromatic and polychromatic SPR imaging with flexible field-of-view option, single-pixel spectral SPR sensing and 2D quantification of thin films with resonant wavelength images.
Surface plasmon resonance is well established for biosensing applications, but commonly limited by complex optical detection. Here, the authors present a plasmonic sensor integrated in a photovoltaic cell, which generates an electronic signal sensitive to the solution refractive index via plasmon interaction
The authors demonstrate a colourimetric imaging method using plasmonic nanoparticles for visualisation of heterochromatin histone markers. Based on the distance-dependent coupling effect, resulting in spectral shifts, they observe reorganisation of histone markers caused by oncogene-induced senescence.
The resonant behaviour of clusters of gold nanoparticles has been tuned by gradually bringing the particles together. The approach could have many applications, including chemical and biological sensing.