Structure determination

Structure determination is a procedure by which the three-dimensional atomic coordinates of a molecule or biomolecule are solved using an analytical technique. Many techniques are used in structure determination, most commonly X-ray crystallography, NMR spectroscopy, electron microscopy and molecular modelling.

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News and Comment

  • News and Views |

    Hydrogenases are very powerful biocatalysts for dihydrogen cleavage. Now, X-ray crystallography shows how [Fe]-hydrogenase requires ligand exchanges at the metal centre and significant molecular motions to open and close its active site to effectively transfer a hydride to an electrophilic organic substrate.

    • Yvain Nicolet
    Nature Catalysis 2, 481-482
  • News and Views |

    Quantitative atomic-scale images of electric potentials at surfaces have now been obtained with a non-contact atomic force microscope by functionalizing the tip as a quantum dot sensor.

    • Mats Persson
  • News and Views |

    Viral mRNA synthesis is an essential step in the influenza virus replication cycle and is a prime target for the development of new antivirals. New structures of the influenza virus RNA polymerase now unveil previously unknown details of influenza virus transcription.

    • Aartjan J. W. te Velthuis
  • Editorial |

    Cryo-electron microscopy is currently one of the most productive structural techniques, especially for large protein complexes such as photosystems. This success is built on a very long history of technological advances.

    Nature Plants 5, 449