Structural biology

Structural biology is the study of the molecular structure and dynamics of biological macromolecules, particularly proteins and nucleic acids, and how alterations in their structures affect their function. Structural biology incorporates the principles of molecular biology, biochemistry and biophysics.

Latest Research and Reviews

  • Research | | open

    Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp) at a 4:2 stoichiometric ratio.

    • Hongwu Qian
    • , Pingping Cao
    • , Miaohui Hu
    • , Shuai Gao
    • , Nieng Yan
    •  & Xin Gong
  • Research | | open

    Histone methyltransferase MLL4 is a transcriptional regulator. Here the authors identify the PHD6 finger of MLL4 as a selective reader of the epigenetic modification H4K16ac and show that a subset of MLL4 chromatin binding sites overlap with H4K16ac-enriched regions, which depends on MOF activity.

    • Yi Zhang
    • , Younghoon Jang
    • , Ji-Eun Lee
    • , JaeWoo Ahn
    • , Longxia Xu
    • , Michael R. Holden
    • , Evan M. Cornett
    • , Krzysztof Krajewski
    • , Brianna J. Klein
    • , Shu-Ping Wang
    • , Yali Dou
    • , Robert G. Roeder
    • , Brian D. Strahl
    • , Scott B. Rothbart
    • , Xiaobing Shi
    • , Kai Ge
    •  & Tatiana G. Kutateladze
  • Research | | open

    CENP-A histone variants replace histones H3 at centromeres. Here the authors use a single-chain antibody fragment (scFv) to stabilize human CENP-A nucleosome containing a native α-satellite DNA and solved its structure by cryo-EM to 2.6 Å resolution, providing insight into the structure and function of the CENP-A nucleosome.

    • Bing-Rui Zhou
    • , K. N. Sathish Yadav
    • , Mario Borgnia
    • , Jingjun Hong
    • , Baohua Cao
    • , Ada L. Olins
    • , Donald E. Olins
    • , Yawen Bai
    •  & Ping Zhang
  • Research | | open

    Multidomain RNA-binding proteins recognize specific target sequences through mechanisms that are not well understood. Here the authors present an integrated approach to define the RNA-binding specificity and RNP topology and apply it to the analysis of the prototypical multidomain RNA-binding protein IMP3.

    • Tim Schneider
    • , Lee-Hsueh Hung
    • , Masood Aziz
    • , Anna Wilmen
    • , Stephanie Thaum
    • , Jacqueline Wagner
    • , Robert Janowski
    • , Simon Müller
    • , Silke Schreiner
    • , Peter Friedhoff
    • , Stefan Hüttelmaier
    • , Dierk Niessing
    • , Michael Sattler
    • , Andreas Schlundt
    •  & Albrecht Bindereif
  • Research |

    A molecular model of STING-mediated signalling is proposed, as structural analysis identifies a crucial motif for the binding of TBK1 to STING, and a separate model involved in IRF-3 binding.

    • Baoyu Zhao
    • , Fenglei Du
    • , Pengbiao Xu
    • , Chang Shu
    • , Banumathi Sankaran
    • , Samantha L. Bell
    • , Mengmeng Liu
    • , Yuanjiu Lei
    • , Xinsheng Gao
    • , Xiaofeng Fu
    • , Fanxiu Zhu
    • , Yang Liu
    • , Arthur Laganowsky
    • , Xueyun Zheng
    • , Jun-Yuan Ji
    • , A. Phillip West
    • , Robert O. Watson
    •  & Pingwei Li
    Nature, 1-5

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