Stem cells

Stem cells are cells that have the capacity to self-renew by dividing and to develop into more mature, specialised cells. Stem cells can be unipotent, multipotent, pluripotent or totipotent, depending on the number of cell types to which they can give rise.

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  • Research |

    The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone.

    • Germán Camargo Ortega
    • , Sven Falk
    • , Pia A. Johansson
    • , Elise Peyre
    • , Loïc Broix
    • , Sanjeeb Kumar Sahu
    • , William Hirst
    • , Thomas Schlichthaerle
    • , Camino De Juan Romero
    • , Kalina Draganova
    • , Stanislav Vinopal
    • , Kaviya Chinnappa
    • , Anna Gavranovic
    • , Tugay Karakaya
    • , Thomas Steininger
    • , Juliane Merl-Pham
    • , Regina Feederle
    • , Wei Shao
    • , Song-Hai Shi
    • , Stefanie M. Hauck
    • , Ralf Jungmann
    • , Frank Bradke
    • , Victor Borrell
    • , Arie Geerlof
    • , Simone Reber
    • , Vijay K. Tiwari
    • , Wieland B. Huttner
    • , Michaela Wilsch-Bräuninger
    • , Laurent Nguyen
    •  & Magdalena Götz
    Nature, 1-5

  • Research | | open

    Fibroblasts can be directly reprogrammed to cardiomyocytes, but reprogramming is less efficient for adult compared to embryonic fibroblasts. Here, the authors find that inhibition of inflammation and Cox-2-prostaglandin-cAMP-IL-1β signaling enhances reprogramming efficiency of adult, but not embryonic fibroblasts.

    • Naoto Muraoka
    • , Kaori Nara
    • , Fumiya Tamura
    • , Hidenori Kojima
    • , Hiroyuki Yamakawa
    • , Taketaro Sadahiro
    • , Kazutaka Miyamoto
    • , Mari Isomi
    • , Sho Haginiwa
    • , Hidenori Tani
    • , Shota Kurotsu
    • , Rina Osakabe
    • , Satoru Torii
    • , Shigeomi Shimizu
    • , Hideyuki Okano
    • , Yukihiko Sugimoto
    • , Keiichi Fukuda
    •  & Masaki Ieda
    Nature Communications 10, 674

  • Research | | open

    In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances RBC production, potentially through the induction of three soluble factors, ANGPTL7, IL33 and SERPINB2.

    • Martha Lopez-Yrigoyen
    • , Cheng-Tao Yang
    • , Antonella Fidanza
    • , Luca Cassetta
    • , A. Helen Taylor
    • , Angela McCahill
    • , Erica Sellink
    • , Marieke von Lindern
    • , Emile van den Akker
    • , Joanne C. Mountford
    • , Jeffrey W. Pollard
    •  & Lesley M. Forrester
    Nature Communications 10, 881

  • Research | | open

    Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.

    • Didac Carmona-Gutierrez
    • , Andreas Zimmermann
    • , Katharina Kainz
    • , Federico Pietrocola
    • , Guo Chen
    • , Silvia Maglioni
    • , Alfonso Schiavi
    • , Jihoon Nah
    • , Sara Mertel
    • , Christine B. Beuschel
    • , Francesca Castoldi
    • , Valentina Sica
    • , Gert Trausinger
    • , Reingard Raml
    • , Cornelia Sommer
    • , Sabrina Schroeder
    • , Sebastian J. Hofer
    • , Maria A. Bauer
    • , Tobias Pendl
    • , Jelena Tadic
    • , Christopher Dammbrueck
    • , Zehan Hu
    • , Christoph Ruckenstuhl
    • , Tobias Eisenberg
    • , Sylvere Durand
    • , Noélie Bossut
    • , Fanny Aprahamian
    • , Mahmoud Abdellatif
    • , Simon Sedej
    • , David P. Enot
    • , Heimo Wolinski
    • , Jörn Dengjel
    • , Oliver Kepp
    • , Christoph Magnes
    • , Frank Sinner
    • , Thomas R. Pieber
    • , Junichi Sadoshima
    • , Natascia Ventura
    • , Stephan J. Sigrist
    • , Guido Kroemer
    •  & Frank Madeo
    Nature Communications 10, 651
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