Stem-cell differentiation

Definition

Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation occurs during development of an organism to produce new specialised cells, and also in adults to replenish cells that are lost.

Latest Research and Reviews

News and Comment

  • News and Views |

    Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.

    • Fiona K. Hamey
    •  & Berthold Göttgens
    Nature Cell Biology 19, 261–263
  • Comments and Opinion |

    Ex vivo organoid culture could revolutionize biology, but variability must be understood.

    • Natalie de Souza