Spike-timing-dependent plasticity articles from across Nature Portfolio

This paper shows that memory engrams are dynamic: neurons drop in and out as engrams become selective during memory consolidation. Inhibition and inhibitory plasticity are crucial for the expression and emergence of memory selectivity, respectively.

Cortical inhibitory interneurons undergo diverse forms of long-term synaptic plasticity. In this Review, Sjöström and colleagues describe the diversity of this interneuron plasticity and highlight that the plasticitome, a comprehensive database of plasticity rules, is needed to understand circuit plasticity complexity.

Using computational modelling this study proposes that the commonly observed depression-to-facilitation shift across development controls excitation-inhibition balance in the brain.

The authors propose a synaptic plasticity rule for pyramidal neurons based on postsynaptic bursting that captures experimental data and solves the credit assignment problem for deep networks.

Evidence for the presence of silent synapses in the visual cortex of adult mice is uncovered.

Dopamine regulates reinforcement-based plasticity at the single-spine level on medium spiny neurons in the striatum by increasing the gain of Hebbian plasticity.

A study shows that NR3A–containing presynaptic NMDA receptors regulate glutamate release, and that a switch in subunit composition underlies the developmental loss of spike timing–dependent LTD at cortical synapses.