Sphingolipids

Sphingolipids are lipids with a sphingoid base backbone, bearing its own hydrocarbon chain, an amine group and two hydroxyl groups. The amine group is bonded to a fatty acid of varying length and one of the hydroxyl groups may be functionalized to a phosphate or carbohydrate. Sphingolipids are involved in signal transduction across membranes.

Latest Research and Reviews

  • Research | | open

    Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to identify the voltage-dependent anion channel VDAC2 as a direct effector of ceramide-mediated cell death.

    • Shashank Dadsena
    • , Svenja Bockelmann
    • , John G. M. Mina
    • , Dina G. Hassan
    • , Sergei Korneev
    • , Guilherme Razzera
    • , Helene Jahn
    • , Patrick Niekamp
    • , Dagmar Müller
    • , Markus Schneider
    • , Fikadu G. Tafesse
    • , Siewert J. Marrink
    • , Manuel N. Melo
    •  & Joost C. M. Holthuis
  • Research | | open

    Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and activation of its downstream targets.

    • Baharan Fekry
    • , Kristen A. Jeffries
    • , Amin Esmaeilniakooshkghazi
    • , Zdzislaw M. Szulc
    • , Kevin J. Knagge
    • , David R. Kirchner
    • , David A. Horita
    • , Sergey A. Krupenko
    •  & Natalia I. Krupenko
  • Research | | open

    Ceramides are signalling molecules that regulate several physiological functions including insulin sensitivity. Here the authors report a selective ceramide synthase 1 inhibitor that counteracts lipid accumulation within the muscle and adiposity by increasing fatty acid oxidation but without affecting insulin sensitivity in mice fed with an obesogenic diet.

    • Nigel Turner
    • , Xin Ying Lim
    • , Hamish D. Toop
    • , Brenna Osborne
    • , Amanda E. Brandon
    • , Elysha N. Taylor
    • , Corrine E. Fiveash
    • , Hemna Govindaraju
    • , Jonathan D. Teo
    • , Holly P. McEwen
    • , Timothy A. Couttas
    • , Stephen M. Butler
    • , Abhirup Das
    • , Greg M. Kowalski
    • , Clinton R. Bruce
    • , Kyle L. Hoehn
    • , Thomas Fath
    • , Carsten Schmitz-Peiffer
    • , Gregory J. Cooney
    • , Magdalene K. Montgomery
    • , Jonathan C. Morris
    •  & Anthony S. Don

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