Spermatogenesis

Spermatogenesis is the development of the mature male germ cells called sperm cells or spermatozoa. Primordial germ cells, the founder cells of the germ line, develop through several immature stages by undergoing mitosis, meiosis and differentiation into the haploid spermatozoa, which carry only one set of chromosomes.

Latest Research and Reviews

  • Research | | open

    Human embryonic stem cells can be differentiated in vitro into primordial germ cell-like cells (PGCLCs) that resemble early primordial germ cells (PGCs). Here the authors transplant PGCLCs generated from rhesus macaque iPSCs into mouse and rhesus macaque seminiferous tubules, which matures these into late PGCs and spermatogonia-like cells.

    • Enrique Sosa
    • , Di Chen
    • , Ernesto J. Rojas
    • , Jon D. Hennebold
    • , Karen A. Peters
    • , Zhuang Wu
    • , Truong N. Lam
    • , Jennifer M. Mitchell
    • , Meena Sukhwani
    • , Ramesh C. Tailor
    • , Marvin L. Meistrich
    • , Kyle E. Orwig
    • , Gunapala Shetty
    •  & Amander T. Clark
  • Research |

    Analysis of 1,007 sibling pairs from 251 families identifies 878 de novo mutations shared by siblings at 448 sites. Recurrence probability based on parental somatic mosaicism, sibling sharing, parent of origin, mutation type and genomic position can range from 0.011% to 28.5%.

    • Hákon Jónsson
    • , Patrick Sulem
    • , Gudny A. Arnadottir
    • , Gunnar Pálsson
    • , Hannes P. Eggertsson
    • , Snaedis Kristmundsdottir
    • , Florian Zink
    • , Birte Kehr
    • , Kristjan E. Hjorleifsson
    • , Brynjar Ö. Jensson
    • , Ingileif Jonsdottir
    • , Sigurdur Einar Marelsson
    • , Sigurjon Axel Gudjonsson
    • , Arnaldur Gylfason
    • , Adalbjorg Jonasdottir
    • , Aslaug Jonasdottir
    • , Simon N. Stacey
    • , Olafur Th. Magnusson
    • , Unnur Thorsteinsdottir
    • , Gisli Masson
    • , Augustine Kong
    • , Bjarni V. Halldorsson
    • , Agnar Helgason
    • , Daniel F. Gudbjartsson
    •  & Kari Stefansson
    Nature Genetics 50, 1674-1680
  • Research | | open

    Paternal contributions to epigenetic inheritance via nucleosomes are poorly understood, as sperm in many organisms replace the majority of nucleosomes with protamines. Here the authors provide evidence that Caenorhabditis elegans sperm retain histone packaging of the genome and provide a histone-based epigenetic memory that is important for germ cell development in offspring.

    • Tomoko M. Tabuchi
    • , Andreas Rechtsteiner
    • , Tess E. Jeffers
    • , Thea A. Egelhofer
    • , Coleen T. Murphy
    •  & Susan Strome
  • Reviews |

    Testicular cancer, which is the most common malignancy among men between 14 and 44 years of age, has a cure rate of >90%. This Primer provides an overview of the biology, epidemiology, diagnosis and current treatment guidelines for testicular cancer, with a focus on germ cell tumours.

    • Liang Cheng
    • , Peter Albers
    • , Daniel M. Berney
    • , Darren R. Feldman
    • , Gedske Daugaard
    • , Timothy Gilligan
    •  & Leendert H. J. Looijenga

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