Small-cell lung cancer

Small-cell lung cancer is a highly malignant form of lung cancer, also known as oat-cell carcinoma, that accounts for approximately 15% of lung cancer cases. Composed of small, ovoid cells with very little cytoplasm, small-cell lung cancer usually originates in the bronchi and is caused by smoking.

Latest Research and Reviews

  • Research | | open

    Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol biosynthetic pathway, due to the toxic accumulation of pathway intermediate squalene.

    • Christopher E. Mahoney
    • , David Pirman
    • , Victor Chubukov
    • , Taryn Sleger
    • , Sebastian Hayes
    • , Zi Peng Fan
    • , Eric L. Allen
    • , Ying Chen
    • , Lingling Huang
    • , Meina Liu
    • , Yingjia Zhang
    • , Gabrielle McDonald
    • , Rohini Narayanaswamy
    • , Sung Choe
    • , Yue Chen
    • , Stefan Gross
    • , Giovanni Cianchetta
    • , Anil K. Padyana
    • , Stuart Murray
    • , Wei Liu
    • , Kevin M. Marks
    • , Joshua Murtie
    • , Marion Dorsch
    • , Shengfang Jin
    • , Nelamangala Nagaraja
    • , Scott A. Biller
    • , Thomas Roddy
    • , Janeta Popovici-Muller
    •  & Gromoslaw A. Smolen
  • Research |

    • Tracy L. Leong
    • , Velimir Gayevskiy
    • , Daniel P. Steinfort
    • , Marc R. De Massy
    • , Alvaro Gonzalez-Rajal
    • , Kieren D. Marini
    • , Emily Stone
    • , Venessa Chin
    • , Adrian Havryk
    • , Marshall Plit
    • , Louis B. Irving
    • , Barton R. Jennings
    • , Rachael A. McCloy
    • , W. Samantha N. Jayasekara
    • , Muhammad Alamgeer
    • , Vishal Boolell
    • , Andrew Field
    • , Prudence A. Russell
    • , Beena Kumar
    • , Daniel J. Gough
    • , Anette Szczepny
    • , Vinod Ganju
    • , Fernando J. Rossello
    • , Jason E. Cain
    • , Anthony T. Papenfuss
    • , Marie-Liesse Asselin-Labat
    • , Mark J. Cowley
    •  & D. Neil Watkins
    Oncogene 38, 1661-1675
  • Research | | open

    Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy resistance.

    • Alex H. Wagner
    • , Siddhartha Devarakonda
    • , Zachary L. Skidmore
    • , Kilannin Krysiak
    • , Avinash Ramu
    • , Lee Trani
    • , Jason Kunisaki
    • , Ashiq Masood
    • , Saiama N. Waqar
    • , Nicholas C. Spies
    • , Daniel Morgensztern
    • , Jason Waligorski
    • , Jennifer Ponce
    • , Robert S. Fulton
    • , Leonard B. Maggi Jr.
    • , Jason D. Weber
    • , Mark A. Watson
    • , Christopher J. O’Conor
    • , Jon H. Ritter
    • , Rachelle R. Olsen
    • , Haixia Cheng
    • , Anandaroop Mukhopadhyay
    • , Ismail Can
    • , Melissa H. Cessna
    • , Trudy G. Oliver
    • , Elaine R. Mardis
    • , Richard K. Wilson
    • , Malachi Griffith
    • , Obi L. Griffith
    •  & Ramaswamy Govindan
  • Research | | open

    Small cell lung cancer (SCLC) may evolve under treatment. But tumor tissues are often not available to study evolution of SCLC. Here, the authors utilize circulating tumor DNA to investigate the genomic evolution and subclonal architecture of SCLC during therapy.

    • Jingying Nong
    • , Yuhua Gong
    • , Yanfang Guan
    • , Xin Yi
    • , Yuting Yi
    • , Lianpeng Chang
    • , Ling Yang
    • , Jialin Lv
    • , Zhirong Guo
    • , Hongyan Jia
    • , Yuxing Chu
    • , Tao Liu
    • , Ming Chen
    • , Lauren Byers
    • , Emily Roarty
    • , Vincent K. Lam
    • , Vassiliki A. Papadimitrakopoulou
    • , Ignacio Wistuba
    • , John V. Heymach
    • , Bonnie Glisson
    • , Zhongxing Liao
    • , J. Jack Lee
    • , P. Andrew Futreal
    • , Shucai Zhang
    • , Xuefeng Xia
    • , Jianjun Zhang
    •  & Jinghui Wang

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