Sleep

Sleep is a state characterized by a reduced responsiveness to sensory stimuli, suppressed locomotor activity and rapid reversibility to wakefulness. It is a process that is evolutionarily conserved in the majority of organisms from worms to humans. In humans it has four stages, each with characteristic and distinctive electroencephalographic (EEG) signatures.

Latest Research and Reviews

  • Research | | open

    GWAS have previously found 24 genomic loci associated with chronotype, an individual’s preference for early or late sleep timing. Here, the authors identify 327 additional loci in a sample of 697,828 individuals and further explore the relationships of chronotype with metabolic and psychiatric diseases.

    • Samuel E. Jones
    • , Jacqueline M. Lane
    • , Andrew R. Wood
    • , Vincent T. van Hees
    • , Jessica Tyrrell
    • , Robin N. Beaumont
    • , Aaron R. Jeffries
    • , Hassan S. Dashti
    • , Melvyn Hillsdon
    • , Katherine S. Ruth
    • , Marcus A. Tuke
    • , Hanieh Yaghootkar
    • , Seth A. Sharp
    • , Yingjie Jie
    • , William D. Thompson
    • , Jamie W. Harrison
    • , Amy Dawes
    • , Enda M. Byrne
    • , Henning Tiemeier
    • , Karla V. Allebrandt
    • , Jack Bowden
    • , David W. Ray
    • , Rachel M. Freathy
    • , Anna Murray
    • , Diego R. Mazzotti
    • , Philip R. Gehrman
    • , Debbie A. Lawlor
    • , Timothy M. Frayling
    • , Martin K. Rutter
    • , David A. Hinds
    • , Richa Saxena
    •  & Michael N. Weedon
  • Reviews |

    Narcolepsy is a sleep disorder caused by selective loss of orexin-producing neurons. Scammell and colleagues describe the functions of orexin neurons and the effects of their loss and review evidence implicating the immune system in the pathogenesis of the disorder.

    • Carrie E. Mahoney
    • , Andrew Cogswell
    • , Igor J. Koralnik
    •  & Thomas E. Scammell
  • Research | | open

    The diagnosis of sleep disorders such as narcolepsy and insomnia currently requires experts to interpret sleep recordings (polysomnography). Here, the authors introduce a neural network analysis method for polysomnography that could reduce time spent in sleep clinics and automate narcolepsy diagnosis.

    • Jens B. Stephansen
    • , Alexander N. Olesen
    • , Mads Olsen
    • , Aditya Ambati
    • , Eileen B. Leary
    • , Hyatt E. Moore
    • , Oscar Carrillo
    • , Ling Lin
    • , Fang Han
    • , Han Yan
    • , Yun L. Sun
    • , Yves Dauvilliers
    • , Sabine Scholz
    • , Lucie Barateau
    • , Birgit Hogl
    • , Ambra Stefani
    • , Seung Chul Hong
    • , Tae Won Kim
    • , Fabio Pizza
    • , Giuseppe Plazzi
    • , Stefano Vandi
    • , Elena Antelmi
    • , Dimitri Perrin
    • , Samuel T. Kuna
    • , Paula K. Schweitzer
    • , Clete Kushida
    • , Paul E. Peppard
    • , Helge B. D. Sorensen
    • , Poul Jennum
    •  & Emmanuel Mignot

News and Comment