Sleep disorders

Sleep disorders are a group of conditions in which the normal sleep pattern or sleep behaviours are disturbed. Primary sleep disorders include insomnia, hypersomnia, obstructive sleep apnoea and parasomnias (abnormal sleep behaviours, such as sleepwalking and rapid eye movement sleep behaviour disorder).

Latest Research and Reviews

  • Research |

    Genome-wide association analyses identify 57 loci associated with insomnia symptoms and provide evidence of shared genetic architecture between insomnia and cardiometabolic, behavioral, psychiatric and reproductive traits.

    • Jacqueline M. Lane
    • , Samuel E. Jones
    • , Hassan S. Dashti
    • , Andrew R. Wood
    • , Krishna G. Aragam
    • , Vincent T. van Hees
    • , Linn B. Strand
    • , Bendik S. Winsvold
    • , Heming Wang
    • , Jack Bowden
    • , Yanwei Song
    • , Krunal Patel
    • , Simon G. Anderson
    • , Robin N. Beaumont
    • , David A. Bechtold
    • , Brian E. Cade
    • , Mary Haas
    • , Sekar Kathiresan
    • , Max A. Little
    • , Annemarie I. Luik
    • , Andrew S. Loudon
    • , Shaun Purcell
    • , Rebecca C. Richmond
    • , Frank A. J. L. Scheer
    • , Barbara Schormair
    • , Jessica Tyrrell
    • , John W. Winkelman
    • , Juliane Winkelmann
    • , Amy E. Martinsen
    • , Anne H. Skogholt
    • , Ben Brumpton
    • , Bendik S. Winsvold
    • , Børge Sivertsen
    • , Cristen J. Willer
    • , Daniela Bragantini
    • , Håvard Kallestad
    • , Imre Janszky
    • , Ismail C. Guzey
    • , John-Anker Zwart
    • , Jonas B. Nielsen
    • , Kristian B. Nilsen
    • , Kristian Hveem
    • , Lars Fritsche
    • , Linda M. Pedersen
    • , Linn B. Strand
    • , Maiken E. Gabrielsen
    • , Marianne B. Johnsen
    • , Marie U. Lie
    • , Morten Engstrøm
    • , Trond Sand
    • , Wei Zhou
    • , Kristian Hveem
    • , Chen Zhao
    • , Jonas B. Nielsen
    • , Cristen J. Willer
    • , Susan Redline
    • , Kai Spiegelhalder
    • , Simon D. Kyle
    • , David W. Ray
    • , John-Anker Zwart
    • , Ben Brumpton
    • , Timothy M. Frayling
    • , Deborah A. Lawlor
    • , Martin K. Rutter
    • , Michael N. Weedon
    •  & Richa Saxena
    Nature Genetics 51, 387-393
  • Reviews |

    Narcolepsy is a sleep disorder caused by selective loss of orexin-producing neurons. Scammell and colleagues describe the functions of orexin neurons and the effects of their loss and review evidence implicating the immune system in the pathogenesis of the disorder.

    • Carrie E. Mahoney
    • , Andrew Cogswell
    • , Igor J. Koralnik
    •  & Thomas E. Scammell
  • Research | | open

    The diagnosis of sleep disorders such as narcolepsy and insomnia currently requires experts to interpret sleep recordings (polysomnography). Here, the authors introduce a neural network analysis method for polysomnography that could reduce time spent in sleep clinics and automate narcolepsy diagnosis.

    • Jens B. Stephansen
    • , Alexander N. Olesen
    • , Mads Olsen
    • , Aditya Ambati
    • , Eileen B. Leary
    • , Hyatt E. Moore
    • , Oscar Carrillo
    • , Ling Lin
    • , Fang Han
    • , Han Yan
    • , Yun L. Sun
    • , Yves Dauvilliers
    • , Sabine Scholz
    • , Lucie Barateau
    • , Birgit Hogl
    • , Ambra Stefani
    • , Seung Chul Hong
    • , Tae Won Kim
    • , Fabio Pizza
    • , Giuseppe Plazzi
    • , Stefano Vandi
    • , Elena Antelmi
    • , Dimitri Perrin
    • , Samuel T. Kuna
    • , Paula K. Schweitzer
    • , Clete Kushida
    • , Paul E. Peppard
    • , Helge B. D. Sorensen
    • , Poul Jennum
    •  & Emmanuel Mignot

News and Comment